Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 14.1, Problem 1CYP
Explain the functions of the three lines of defense and indicate which are the most essential to survival.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 14 Solutions
Foundations in Microbiology
Ch. 14.1 - Summarize the characteristics of basic host...Ch. 14.1 - Differentiate between the three lines of defense,...Ch. 14.1 - Explain the nature of the different types of...Ch. 14.1 - Explain the functions of the three lines of...Ch. 14.1 - What is the difference between nonspecific host...Ch. 14.1 - Differentiate innate defenses and acquired...Ch. 14.1 - List four innate defensive responses present in...Ch. 14.2 - Prob. 4ELOCh. 14.2 - Describe several features of the recognition...Ch. 14.2 - Characterize pattern recognition receptors and...
Ch. 14.2 - Describe the microscopic anatomy of body...Ch. 14.2 - Prob. 8ELOCh. 14.2 - Prob. 9ELOCh. 14.2 - Prob. 10ELOCh. 14.2 - Prob. 11ELOCh. 14.2 - Prob. 5CYPCh. 14.2 - Prob. 6CYPCh. 14.2 - Prob. 7CYPCh. 14.2 - What are the main components of the...Ch. 14.2 - Prob. 9CYPCh. 14.2 - Prob. 10CYPCh. 14.2 - Prob. 11CYPCh. 14.2 - Prob. 12CYPCh. 14.2 - Describe the principal function of the two...Ch. 14.2 - What is Lymph, and how is it formed?Ch. 14.2 - Prob. 15CYPCh. 14.3 - Describe the main events in the inflammatory...Ch. 14.3 - Prob. 13ELOCh. 14.3 - Describe the mechanism behind fever, and explain...Ch. 14.3 - Describe the major events in the inflammatory...Ch. 14.3 - Of rubor, calor, dolor, and tumor, which are signs...Ch. 14.3 - Prob. 18CYPCh. 14.3 - Prob. 19CYPCh. 14.3 - Prob. 20CYPCh. 14.3 - Prob. 21CYPCh. 14.3 - Explain the processes of diapedesis and...Ch. 14.3 - Prob. 23CYPCh. 14.4 - Prob. 15ELOCh. 14.4 - Indicate the major stages of phagocytosis, and...Ch. 14.4 - Prob. 17ELOCh. 14.4 - Prob. 18ELOCh. 14.4 - Characterize the complement system, its origins,...Ch. 14.4 - Prob. 24CYPCh. 14.4 - What are the types of macrophages, and what are...Ch. 14.4 - Prob. 26CYPCh. 14.4 - Prob. 27CYPCh. 14.4 - Prob. 28CYPCh. 14.4 - Prob. 29CYPCh. 14.4 - Prob. 30CYPCh. 14.4 - Using figure 14.21 as a guide, give examples for...Ch. 14.L1 - An example/examples of a nonspecific chemical...Ch. 14.L1 - Prob. 2MCQCh. 14.L1 - Prob. 3MCQCh. 14.L1 - Prob. 4MCQCh. 14.L1 - What is included in GALT? a. thymus b. Peyer’s...Ch. 14.L1 - Prob. 6MCQCh. 14.L1 - Monocytes are ___________ leukocytes that develop...Ch. 14.L1 - Prob. 8MCQCh. 14.L1 - Toll-like receptors are proteins on ___________ a....Ch. 14.L1 - Prob. 10MCQCh. 14.L1 - __________ is an example of an inflammatory...Ch. 14.L1 - Prob. 12MCQCh. 14.L1 - _________ interferon, produced by T lymphocytes,...Ch. 14.L1 - In what process is tumor necrosis factor (TNF) not...Ch. 14.L1 - Which of the following substances is not produced...Ch. 14.L1 - Prob. 16MCQCh. 14.L1 - Prob. 1CSRCh. 14.L1 - Prob. 2CSRCh. 14.L1 - Prob. 3CSRCh. 14.L1 - Use the lines on the figure to the right to locate...Ch. 14.L1 - Prob. 2WCCh. 14.L1 - Prob. 3WCCh. 14.L1 - Prob. 4WCCh. 14.L1 - Prob. 5WCCh. 14.L1 - Prob. 6WCCh. 14.L1 - Prob. 7WCCh. 14.L1 - Prob. 8WCCh. 14.L1 - Prob. 9WCCh. 14.L1 - Prob. 10WCCh. 14.L2 - Suggest some reasons that there is so much...Ch. 14.L2 - Prob. 2CTCh. 14.L2 - Prob. 3CTCh. 14.L2 - Prob. 4CTCh. 14.L2 - An obsolete treatment for syphilis involved...Ch. 14.L2 - Patients with a history of tuberculosis often show...Ch. 14.L2 - Shigella, Mycobacterium, and numerous other...Ch. 14.L2 - Account for the several inflammatory symptoms that...Ch. 14.L2 - Prob. 9CTCh. 14.L2 - Prob. 10CTCh. 14.L2 - Prob. 1VC
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