EBK RESEARCH METHODS FOR THE BEHAVIORAL
EBK RESEARCH METHODS FOR THE BEHAVIORAL
6th Edition
ISBN: 8220106720271
Author: Forzano
Publisher: YUZU
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Chapter 14, Problem 3E

Traditional statistics (means, variances, and hypothesis tests) are not used to evaluate the results from a single-case study. Explain how the results are evaluated.

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In a crossover trial comparing a new drug to a standard, π denotes the probabilitythat the new one is judged better. It is desired to estimate π and test H0 : π = 0.5against H1 : π = 0.5. In 20 independent observations, the new drug is better eachtime.(a) Find and plot the likelihood function. Give the ML estimate of π (Hint: youmay use the plot function in R)
Can you explain what this analysis means in layman's terms?   - We calculated that a target sample size of 3626, which was based on anticipated baseline 90-day mortality of 22% and a noninferiority margin of no more than 4 percentage points, would give the trial 80% power, at a one-sided alpha level of 2.5%, accounting for a maximum of 5% loss to follow-up and for early stopping rules for three interim analyses.-
Can you help me understand this analysis? A 95.7% confidence interval is shown for the intention-to-treat analysis (accounting for alpha spending in interim analyses), and 95% confidence intervals are shown for the other two analyses. The widths of the confidence intervals have not been adjusted for multiplicity. The dashed line indicates the noninferiority margin of 4 percentage points.
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