The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide. Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide. Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

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Answer 1

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Chapter 14, Problem 14.36SP

(a)

Interpretation Introduction

To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.

Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

(b)

Interpretation Introduction

To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.

Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

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Classify each of the following molecules as aromatic, antiaromatic, or nonaromatic. ZI NH Explanation Check O aromatic O antiaromatic O nonaromatic O aromatic O antiaromatic H O nonaromatic O aromatic O antiaromatic O nonaromatic ×

Part I. Draw the stepwise reaction mechanism of each product (a, b, c, d, e, f) HO HO OH НОН,С HO OH Sucrose HO CH₂OH H N N HO -H H -OH KMnO4, Heat H OH CH₂OH (d) Phenyl Osatriazole OH НОН,С HO HO + Glacial HOAC HO- HO CH₂OH OH HO Fructose (a) Glucose OH (b) H₂N HN‍ (c) CuSO4-5H2O, ethanol H N N N HO ·H H OH H OH N CH₂OH OH (f) Phenyl Osazone H (e) Carboxy phenyl osatriazole Figure 2.1. Reaction Scheme for the Total Synthesis of Fine Chemicals

Answer 2

Question

Chapter 14, Problem 14.36SP

(a)

Interpretation Introduction

To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.

Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

(b)

Interpretation Introduction

To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.

Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

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Answer 3

Question

Chapter 14, Problem 14.36SP

(a)

Interpretation Introduction

To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.

Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

(b)

Interpretation Introduction

To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.

Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

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Answer 4

Question

Chapter 14, Problem 14.36SP

(a)

Interpretation Introduction

To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.

Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

(b)

Interpretation Introduction

To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.

Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

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Answer 5

Chapter 14, Problem 14.36SP

(a)

Interpretation Introduction

To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.

Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

(b)

Interpretation Introduction

To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.

Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

Answer 6

Chapter 14, Problem 14.36SP

(a)

Interpretation Introduction

To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.

Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

Answer 7

Chapter 14, Problem 14.36SP

(a)

Interpretation Introduction

To determine: The method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.

Interpretation: The method of synthesis of given compounds is to be stated by reaction of Grignard reagent and an epoxide.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

Answer 8

(b)

Interpretation Introduction

To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.

Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

Answer 9

(b)

Interpretation Introduction

To determine: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent.

Interpretation: The reagents required to synthesis given alcohols and the reason for the reaction to be unlikely to succeed with Grignard reagent is to be stated.

Concept introduction: Steric hinderance limits Grignard reactions. The yield of reaction of Grignard reagents with ethylene oxide and monsubstituted epoxides is high. But the yield is much lower with disubstituted epoxides. Grignard reagents hardly react with tri or tetrasubstituted epoxides.

Answer 10

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Answer 11

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Answer 13

Ch. 14.2C - Rank the given solvents in decreasing order of...Ch. 14.2D - Prob. 14.2P Ch. 14.2D - In the presence of 18-crown-6, potassium...Ch. 14.3B - Give a common name (when possible) and a...Ch. 14.3C - Prob. 14.5P Ch. 14.3C - Name the following heterocyclic ethers.Ch. 14.4 - Propose a fragmentation to account for each...Ch. 14.5 - Prob. 14.8P Ch. 14.5 - Prob. 14.9P Ch. 14.6 - Prob. 14.10P

Solution Summary: The author explains the method of synthesis of given compounds by reaction of Grignard reagent and an epoxide.

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