Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Chapter 13.1, Problem 5AYP
Describe the major histocompatibility complex in two sentences.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 13 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 13.1 - Prob. 1AYPCh. 13.1 - Compare the terms antigen, immunogen, and epitope.Ch. 13.1 - Prob. 3AYPCh. 13.1 - Prob. 4AYPCh. 13.1 - Describe the major histocompatibility complex in...Ch. 13.1 - Prob. 1NPCh. 13.2 - Prob. 6AYPCh. 13.2 - Prob. 7AYPCh. 13.2 - Prob. 8AYPCh. 13.2 - Prob. 9AYP
Ch. 13.2 - Prob. 1MMCh. 13.2 - Prob. 2MMCh. 13.3 - List characteristics of antigens that optimize...Ch. 13.3 - Prob. 11AYPCh. 13.3 - Prob. 12AYPCh. 13.3 - Prob. 2NPCh. 13.4 - Prob. 13AYPCh. 13.4 - Explain how naive T cells become sensitized to an...Ch. 13.4 - Prob. 15AYPCh. 13.5 - Diagram the steps in B-cell activation, including...Ch. 13.5 - Prob. 17AYPCh. 13.5 - Explain the various end results of antibody...Ch. 13.5 - Prob. 19AYPCh. 13.5 - Draw and label a graphwith time on the horizontal...Ch. 13.6 - Prob. 21AYPCh. 13.6 - Discuss the qualities of an effective vaccine.Ch. 13.6 - Name the two major categories of vaccines and then...Ch. 13.6 - Explain the principle of herd immunity and the...Ch. 13.6 - 3. Which characteristic is associated with passive...Ch. 13 - A single bacterium has _______ epitope(s). a. a...Ch. 13 - Prob. 2QCh. 13 - Provide an explanation to refute the following...Ch. 13 - The primary B-cell receptor is a. IgD. b. IgA. c....Ch. 13 - Name three antigen-presenting cells, and what...Ch. 13 - Major histocompatibility molecules are critical...Ch. 13 - In humans, B cells mature in the ___ and T cells...Ch. 13 - Explain how the memory response is the cornerstone...Ch. 13 - Conduct research on clonal deletion and write a...Ch. 13 - Which of the following cells is capable of...Ch. 13 - Is antibody diversity generated at the DNA or RNA...Ch. 13 - In order for gene rearrangement of antigen...Ch. 13 - Prob. 13QCh. 13 - Prob. 14QCh. 13 - Using the details of T-cell activation, suggest a...Ch. 13 - A vaccine that contains parts of viruses is called...Ch. 13 - Explain how herd immunity works to protect the...Ch. 13 - Prob. 18QCh. 13 - Prob. 19QCh. 13 - Chronic lymphocytic leukemia leads to the...Ch. 13 - Prob. 21QCh. 13 - Prob. 1VC
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