The autonomic nervous system is a functional division of the peripheral nervous system. It involves two autonomic neurons in the efferent pathway, namely preganglionic neurons and postganglionic neurons. The cell body of the preganglionic neurons is in the central nervous system (CNS), whereas the postganglionic neurons lie entirely outside the CNS. The autonomic nervous system is (structurally and functionally) divided into two parts, namely the sympathetic nervous system (SNS) and the parasympathetic nervous system (PSNS).

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The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions. 1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction? 2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe: a) What molecule do you recommend for the trial. Why? b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for? 3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale. 4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale. Mutation 1 Mutation 2

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Chapter 13, Problem 6SQ

Summary Introduction

Introduction: The autonomic nervous system is a functional division of the peripheral nervous system. It involves two autonomic neurons in the efferent pathway, namely preganglionic neurons and postganglionic neurons. The cell body of the preganglionic neurons is in the central nervous system (CNS), whereas the postganglionic neurons lie entirely outside the CNS. The autonomic nervous system is (structurally and functionally) divided into two parts, namely the sympathetic nervous system (SNS) and the parasympathetic nervous system (PSNS).

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