Anatomy and Physiology by OpenStax
17th Edition
ISBN: 9781506698021
Author: J. Gordon Betts;Dean H. Kruse;Kelly A. Young;Peter DeSaix;Brandon Poe;Oksana Korol;James A. Wise;Eddie Johnson;Jody E. Johnson;Mark Womble
Publisher: XANEDU PUBLISHING
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Textbook Question
Chapter 13, Problem 39CTQ
Why are ganglia and nerves not surrounded by protective structures like the meninges of the CNS?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 13 Solutions
Anatomy and Physiology by OpenStax
Ch. 13 - Watch this animation...Ch. 13 - Watch this video...Ch. 13 - Watch this video...Ch. 13 - Watch this video...Ch. 13 - Watch this video...Ch. 13 - Compared with the nearest evolutionary relative,...Ch. 13 - Watch this animation...Ch. 13 - Watch this video...Ch. 13 - Watch this animation...Ch. 13 - Figure 13.20 If you zoom in on the DRG, you can...
Ch. 13 - Figure 13.22 To what structures in a skeletal...Ch. 13 - Visit this site...Ch. 13 - Aside from the nervous system, which other organ...Ch. 13 - Which primary vesicle of the embryonic nervous...Ch. 13 - Which adult structure(s) arises from the...Ch. 13 - Which non-nervous tissue develops from the...Ch. 13 - Which structure is associated with the embryologic...Ch. 13 - Which lobe of the cerebral cortex is responsible...Ch. 13 - What region of the diencephalon coordinates...Ch. 13 - What level of the brain stem is the major input to...Ch. 13 - What region of the spinal cord contains motor...Ch. 13 - Brodmanns areas map different regions of the...Ch. 13 - What blood vessel enters the cranium to supply the...Ch. 13 - Which layer of the meninges surrounds and supports...Ch. 13 - What type of glial cell is responsible for...Ch. 13 - Which portion of the ventricular system is found...Ch. 13 - What condition causes a stroke? inflammation of...Ch. 13 - What type of ganglion contains neurons that...Ch. 13 - Which ganglion is responsible for cutaneous...Ch. 13 - What is the name for a bundle of axons within a...Ch. 13 - Which cranial nerve does not control functions in...Ch. 13 - Which of these structures is not under direct...Ch. 13 - Studying the embryonic development of the nervous...Ch. 13 - What happens in development that suggests that...Ch. 13 - Damage to specific regions of the cerebral cortex,...Ch. 13 - Why do the anatomical inputs to the cerebellum...Ch. 13 - Why can the circle of Willis maintain perfusion of...Ch. 13 - Meningitis is an inflammation of the meninges that...Ch. 13 - Why are ganglia and nerves not surrounded by...Ch. 13 - Testing for neurological function involves a...
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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