Concept explainers
Introduction: Molecules that are formed from the transcription of DNAs but do not get translated to proteins are called non-coding RNAs (ncRNAs). nRNAs affect gene expression. Examples of ncRNAs that are involved in epigenetics are miRNAs, piRNAs and siRNAs.

Answer to Problem 1TY
Correct answer: DNA and RNA both bind to an ncRNA through base pairing. Hence, the correct answer is option e.
Explanation of Solution
Reason for correct answer:
Many different functions are carried out by ncRNAs because they have the ability to bind with many different types of molecules, such as DNA, other mRNAs, proteins or other small molecules. ncRNAs can affect different processes, such as
Option e. is given as “both a and b”.
The types of molecules that could bind to an ncRNA through base pairing are DNA and RNA. Hence, the correct answer is option e.
Reasons for incorrect answer:
Option a. is given as, “DNA”.
ncRNAs affect gene expression by binding to different molecules, such as DNA, mRNA, proteins, and small molecules. They play a very important role in affecting transcriptional, post-transcriptional, and epigenetic regulation. On binding to DNA molecules, ncRNAs may affect DNA replication, transcription, and translation. This is possible through complementary base pairing of ncRNAs with DNA strands. However, ncRNAs bind to both RNAs and DNAs. Hence, option a. is incorrect.
Option b. is given as, “RNA”.
By binding to different molecules, such as DNA, mRNA, proteins, and small molecules, ncRNAs affect gene expression. Transcriptional, post-transcriptional and epigenetic regulation occurs as a result of this binding. Binding of ncRNAs to other mRNAs is possible through complementary base pairing. However, ncRNAs bind to both DNAs and RNAs. Hence, option b. is incorrect.
Option c. is given as, “protein”.
ncRNAs bind to different molecules such as DNA, mRNA, proteins and small molecules. They play a very important role in affecting transcriptional, post-transcriptional, and epigenetic regulation. Binding of ncRNAs with proteins does not occur by the process of complementary base pairing as proteins do not have bases. Hence, option c. is incorrect.
Option d. is given as, “small molecule”.
Small molecules bind to ncRNAs and help in maintaining transcriptional, post-transcriptional, and epigenetic regulation. Binding of ncRNAs with small molecules does not occur by the process of complementary base pairing as small molecules do not have bases. Hence, option d. is incorrect.
Hence, the options a., b., c., and d. are incorrect.
Thus, DNA and RNA both bind to ncRNA through base pairing to carry out regulation of transcription, translation, and epigenetic modifications.
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