Why the sequencing whole genomes present a challenge. Concept introduction: The genome refers to the total genetic material present in an organism. The determination of complete DNA sequences of an organism’s genome is called genome sequencing. There are various methods by which genomes can be sequenced such as Sanger sequencing method, shotgun sequencing method, pyrosequencing and others.

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Answer 1

Question

Chapter 13, Problem 1QC

Summary Introduction

To determine:

Why the sequencing whole genomes present a challenge.

Concept introduction:

The genome refers to the total genetic material present in an organism. The determination of complete DNA sequences of an organism’s genome is called genome sequencing. There are various methods by which genomes can be sequenced such as Sanger sequencing method, shotgun sequencing method, pyrosequencing and others.

Expert Solution & Answer

Explanation of Solution

The whole genome contains millions of DNA base pairs. The whole genome cannot be sequenced as such and therefore, the DNA strand is broken down into smaller fragments. The smaller fragments are then sequenced by sequencing machines to yield sequence of the DNA fragment.

One fragment is sequenced multiple times to avoid errors and therefore, a large number of fragments sequenced yields enormous amount of data that needs to be properly assembled to generate the correct sequence of the DNA. This task is particularly very difficult and possesses a challenge in sequencing of genomes.

Conclusion

The assembly of large amount of overlapping sequences of smaller fragments of DNA is very difficult that makes genome sequencing a challenging task.

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Q8. A researcher wants to study the effectiveness of a pill intended to reduce stomach heartburn in pregnant women. The researcher chooses randomly 400 women to participate in this experiment for 9 months of their pregnancy period. They all need to have the same diet. The researcher designs two groups of 200 participants: One group take the real medication intended to reduce heartburn, while the other group take placebo medication. In this study what are: Independent variable: Dependent variable: Control variable: Experimental group: " Control group: If the participants do not know who is consuming the real pills and who is consuming the sugar pills. This study is It happens that 40% of the participants do not find the treatment helpful and drop out after 6 months. The researcher throws out the data from subjects that drop out. What type of bias is there in this study? If the company who makes the medication funds this research, what type of bias might exist in this research work?

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Answer 2

Question

Chapter 13, Problem 1QC

Summary Introduction

To determine:

Why the sequencing whole genomes present a challenge.

Concept introduction:

The genome refers to the total genetic material present in an organism. The determination of complete DNA sequences of an organism’s genome is called genome sequencing. There are various methods by which genomes can be sequenced such as Sanger sequencing method, shotgun sequencing method, pyrosequencing and others.

Expert Solution & Answer

Explanation of Solution

The whole genome contains millions of DNA base pairs. The whole genome cannot be sequenced as such and therefore, the DNA strand is broken down into smaller fragments. The smaller fragments are then sequenced by sequencing machines to yield sequence of the DNA fragment.

One fragment is sequenced multiple times to avoid errors and therefore, a large number of fragments sequenced yields enormous amount of data that needs to be properly assembled to generate the correct sequence of the DNA. This task is particularly very difficult and possesses a challenge in sequencing of genomes.

Conclusion

The assembly of large amount of overlapping sequences of smaller fragments of DNA is very difficult that makes genome sequencing a challenging task.

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Answer 3

Question

Chapter 13, Problem 1QC

Summary Introduction

To determine:

Why the sequencing whole genomes present a challenge.

Concept introduction:

The genome refers to the total genetic material present in an organism. The determination of complete DNA sequences of an organism’s genome is called genome sequencing. There are various methods by which genomes can be sequenced such as Sanger sequencing method, shotgun sequencing method, pyrosequencing and others.

Expert Solution & Answer

Explanation of Solution

The whole genome contains millions of DNA base pairs. The whole genome cannot be sequenced as such and therefore, the DNA strand is broken down into smaller fragments. The smaller fragments are then sequenced by sequencing machines to yield sequence of the DNA fragment.

One fragment is sequenced multiple times to avoid errors and therefore, a large number of fragments sequenced yields enormous amount of data that needs to be properly assembled to generate the correct sequence of the DNA. This task is particularly very difficult and possesses a challenge in sequencing of genomes.

Conclusion

The assembly of large amount of overlapping sequences of smaller fragments of DNA is very difficult that makes genome sequencing a challenging task.

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Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 4

Question

Chapter 13, Problem 1QC

Summary Introduction

To determine:

Why the sequencing whole genomes present a challenge.

Concept introduction:

The genome refers to the total genetic material present in an organism. The determination of complete DNA sequences of an organism’s genome is called genome sequencing. There are various methods by which genomes can be sequenced such as Sanger sequencing method, shotgun sequencing method, pyrosequencing and others.

Expert Solution & Answer

Explanation of Solution

The whole genome contains millions of DNA base pairs. The whole genome cannot be sequenced as such and therefore, the DNA strand is broken down into smaller fragments. The smaller fragments are then sequenced by sequencing machines to yield sequence of the DNA fragment.

One fragment is sequenced multiple times to avoid errors and therefore, a large number of fragments sequenced yields enormous amount of data that needs to be properly assembled to generate the correct sequence of the DNA. This task is particularly very difficult and possesses a challenge in sequencing of genomes.

Conclusion

The assembly of large amount of overlapping sequences of smaller fragments of DNA is very difficult that makes genome sequencing a challenging task.

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Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 5

Chapter 13, Problem 1QC

Summary Introduction

To determine:

Why the sequencing whole genomes present a challenge.

Concept introduction:

The genome refers to the total genetic material present in an organism. The determination of complete DNA sequences of an organism’s genome is called genome sequencing. There are various methods by which genomes can be sequenced such as Sanger sequencing method, shotgun sequencing method, pyrosequencing and others.

Expert Solution & Answer

Explanation of Solution

The whole genome contains millions of DNA base pairs. The whole genome cannot be sequenced as such and therefore, the DNA strand is broken down into smaller fragments. The smaller fragments are then sequenced by sequencing machines to yield sequence of the DNA fragment.

One fragment is sequenced multiple times to avoid errors and therefore, a large number of fragments sequenced yields enormous amount of data that needs to be properly assembled to generate the correct sequence of the DNA. This task is particularly very difficult and possesses a challenge in sequencing of genomes.

Conclusion

The assembly of large amount of overlapping sequences of smaller fragments of DNA is very difficult that makes genome sequencing a challenging task.

Answer 6

Chapter 13, Problem 1QC

Summary Introduction

To determine:

Why the sequencing whole genomes present a challenge.

Concept introduction:

The genome refers to the total genetic material present in an organism. The determination of complete DNA sequences of an organism’s genome is called genome sequencing. There are various methods by which genomes can be sequenced such as Sanger sequencing method, shotgun sequencing method, pyrosequencing and others.

Expert Solution & Answer

Explanation of Solution

The whole genome contains millions of DNA base pairs. The whole genome cannot be sequenced as such and therefore, the DNA strand is broken down into smaller fragments. The smaller fragments are then sequenced by sequencing machines to yield sequence of the DNA fragment.

One fragment is sequenced multiple times to avoid errors and therefore, a large number of fragments sequenced yields enormous amount of data that needs to be properly assembled to generate the correct sequence of the DNA. This task is particularly very difficult and possesses a challenge in sequencing of genomes.

Conclusion

The assembly of large amount of overlapping sequences of smaller fragments of DNA is very difficult that makes genome sequencing a challenging task.

Answer 7

Chapter 13, Problem 1QC

Summary Introduction

To determine:

Why the sequencing whole genomes present a challenge.

Concept introduction:

The genome refers to the total genetic material present in an organism. The determination of complete DNA sequences of an organism’s genome is called genome sequencing. There are various methods by which genomes can be sequenced such as Sanger sequencing method, shotgun sequencing method, pyrosequencing and others.

Answer 8

Expert Solution & Answer

Explanation of Solution

The whole genome contains millions of DNA base pairs. The whole genome cannot be sequenced as such and therefore, the DNA strand is broken down into smaller fragments. The smaller fragments are then sequenced by sequencing machines to yield sequence of the DNA fragment.

One fragment is sequenced multiple times to avoid errors and therefore, a large number of fragments sequenced yields enormous amount of data that needs to be properly assembled to generate the correct sequence of the DNA. This task is particularly very difficult and possesses a challenge in sequencing of genomes.