To analyze:
The expression of UG
From the given information, following questions are asked.
Explanation on reason for different impacts of deletions B and F on expression in stem tissue and leaf tissue.
Explanation on reason for deletion of D allows UG
Explanation on reason for deletion of E reduces UG
Introduction:
A eukaryotic gene has regulatory sequences which comprises of promoters, enhancers, and silencers which collectively control the gene expression.
Enhancers are present upstream of the promoter sequence. Binding of the enzymes and the transcription factor to the enhancer sequences bring about the regulation of the transcription of the gene. Enhancers are termed as positive cis acting elements as they act on the gene present on the same strand; it can also affect the gene which is
Promoter is the sequence of nucleotides on DNA where RNA polymerase is recruited to carry out the transcription of the particular gene. Promoters’ sequences are observed to highly conserve through evolution therefore calling them consensus sequences. In prokaryotes, the promoter comprises of the sequence called as TATA BOX (TATAAT) at
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Genetic Analysis: An Integrated Approach (3rd Edition)
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- A second hit might occur through epigenetic modification. There is a CpG island in the RB1 promoter. What epigenetic modification is associated with CpG islands? What does this type of modification usually do to gene expression? How could this CpG island/this epigenetic modification be related toRB1 expression and retinoblastoma?arrow_forwardThe following question refers to the transcriptional control of the Gal7locus in Saccramyces cerevisiae. What is the predicted Gal7 expression phenotype (inducible,uninducible, constitutive) of the following mutant strains?arrow_forwardThe GA(T>C)A mutation in the Duffy promoter impacted expression of Duffy in the following cell types... O Blood cells O Endothelial cells O Purkinje cells O Purkinje, Endolthelial, and Blood cells.arrow_forward
- Which of the following is true when considering the calcineuron-NFAT pathway? Choose all that are true. Calcineuron removes Pi from NFATC in the presence of Ca2+. Trisomy 21 alters the dosage of DYRK1A and calcineuron. The addition of Pi to NFATc results in an increase in gene expression. The removal of Pi from NFATC is inhibited by DSCR1.arrow_forwardTumor cells from a person with leukemia have been analyzed to determine which oncogene is involved in the transformation. After partial sequencing of the gene, the predicted gene product is identified as a tyrosine kinase. Which of the following proteins would most likely be encoded by an oncogene and exhibit tyrosine kinase activity? A. Nuclear transcriptional activator B. Epidermal growth factor C. Membrane-associated G protein D. Platelet-derived growth factor E. Growth factor receptorarrow_forwardWhat is cell differentiation? Discuss the role of myogenic bHLH proteins in the differentiation of muscle cells. Explain how they work at the molecular level. In your answer, explain how protein dimerization is key to gene regulation.arrow_forward
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