Chapter 13, Problem 13.142AP

(a)

Interpretation Introduction

To determine: The structures of the acid and alcohol formed by the metabolism of Tamiflu.

Interpretation: The structure of Tamiflu is given. The structures of the products formed by the metabolism of Tamiflu in the liver are to be drawn.

Concept introduction: The hydrolysis of an ester is the reaction in which a water molecule breaks the ester bond and adds a proton to the carboxylate group of one species and the hydroxide group to the alkyl group of the other species.

(b)

Interpretation Introduction

To determine: The functional group other that acidic group and chiral center in the structure of the active form of Tamiflu drug.

Interpretation: The functional group other that acidic group and chiral center in the structure of the active form of Tamiflu drug are to be identified.

Concept introduction: Functional group is a group of atoms responsible for the reactivity of the compound. Chiral center in a compound is the carbon that is attached to four different groups in a compound.