Essential Cell Biology (Fourth Edition)
4th Edition
ISBN: 9780815345251
Author: Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D. Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 13, Problem 11Q
Summary Introduction
To explain: The free energy change for hydrolysis of phosphate bond in creatine phosphate is useful to store energy in muscle cells.
Concept introduction: The creatine phosphate is a phophorylated creatine molecule in the muscle cells, which serves as rapidly movable storage of high-energy phosphates that rearrange the energy molecule of the cell called the adenosine triphosphate (ATP).
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
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c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
Chapter 13 Solutions
Essential Cell Biology (Fourth Edition)
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