Microbiology with Diseases by Body System (5th Edition)
Microbiology with Diseases by Body System (5th Edition)
5th Edition
ISBN: 9780134477206
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 13, Problem 11CT
Summary Introduction

To answer:

The advantage of reverse transcriptase enzyme by retrovirus over positive sense single-stranded RNA.

Introduction:

The virus genetic material is composed of either DNA or RNA, but not both. Their genetic material is classified into double-stranded DNA (hepatitis B virus), single-stranded DNA (parvovirus), single-stranded RNA (poliovirus), and double-stranded RNA (rotavirus).

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Although many +ssRNA viruses use their genomr directly as mRNA retroviruses do not. instead their +RNA is transcribed into a DNA by a resverse transcriptase. what advantages do retroviruses gained by using reserve transcriptase?
Some retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome? Multiple Choice The virus carries genes that will interfere with host cell activities. The viral DNA sequences could still cause a disease. Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either. The integration could disrupt an essential gene or genes.
Coronaviruses have a positive-sense single stranded RNA genome. a.) What is the genome replication strategy of this category of viruses? b.) How do you think this feature affects the stability of the viral genome? (hint use figure below)   Mutation rates in different types of viruses. Estimates obtained for viruses belonging to the major indicated groups are shown as a function of genome size. This reveals an effect of genetic material (RNA/DNA) and genome size on viral mutation rates.
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What Is A Virus ? ; Author: Peekaboo Kidz;https://www.youtube.com/watch?v=YS7vsBgWszI;License: Standard YouTube License, CC-BY