Microbiology with Diseases by Body System (5th Edition)
5th Edition
ISBN: 9780134477206
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 13, Problem 11CT
Summary Introduction
To answer:
The advantage of reverse transcriptase enzyme by retrovirus over positive sense single-stranded RNA.
Introduction:
The virus genetic material is composed of either DNA or RNA, but not both. Their genetic material is classified into double-stranded DNA (hepatitis B virus), single-stranded DNA (parvovirus), single-stranded RNA (poliovirus), and double-stranded RNA (rotavirus).
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Although many +ssRNA viruses use their genomr directly as mRNA retroviruses do not. instead their +RNA is transcribed into a DNA by a resverse transcriptase. what advantages do retroviruses gained by using reserve transcriptase?
Some retroviruses that have a wide host range have been developed for use in treatment of diseases or syndromes. These viruses do not result in a productive infection because they lack critical genes for viral
replication, but they do carry DNA sequences that allow them to be packaged into infectious particles. Once in the host cell the viral DNA is released and integrates into the cell's genome. The advantage to this
strategy is that the delivery of the DNA is very efficient. What is one possible problem of using a virus that can integrate into the human nuclear genome?
Multiple Choice
The virus carries genes that will interfere with host cell activities.
The viral DNA sequences could still cause a disease.
Since the viral DNA sequences no longer contain essential genes for viral replication the host cell may not be able to replicate either.
The integration could disrupt an essential gene or genes.
Coronaviruses have a positive-sense single stranded RNA genome.
a.) What is the genome replication strategy of this category of viruses?
b.) How do you think this feature affects the stability of the viral genome? (hint use figure below)
Mutation rates in different types of viruses. Estimates obtained for viruses belonging to the major indicated groups are shown as a function of genome size. This reveals an effect of genetic material (RNA/DNA) and genome size on viral mutation rates.
Chapter 13 Solutions
Microbiology with Diseases by Body System (5th Edition)
Ch. 13 - Why are naked icosahedral viruses able to...Ch. 13 - What characteristics of the genomes of...Ch. 13 - Prob. 3TMWCh. 13 - Prob. 1EDCSCh. 13 - Prob. 4TMWCh. 13 - Prob. 5TMWCh. 13 - Prob. 6TMWCh. 13 - Prob. 7TMWCh. 13 - Prob. 1CCSCh. 13 - Prob. 1MC
Ch. 13 - Prob. 2MCCh. 13 - Prob. 3MCCh. 13 - Prob. 4MCCh. 13 - Prob. 5MCCh. 13 - Prob. 6MCCh. 13 - Prob. 7MCCh. 13 - Prob. 8MCCh. 13 - Prob. 9MCCh. 13 - Prob. 10MCCh. 13 - Prob. 1MCh. 13 - Prob. 1VICh. 13 - Prob. 2VICh. 13 - Prob. 1SACh. 13 - Prob. 2SACh. 13 - Prob. 3SACh. 13 - Prob. 4SACh. 13 - Prob. 5SACh. 13 - What is the difference between a virion and a...Ch. 13 - How is a provirus like a prophage? How is it...Ch. 13 - Prob. 8SACh. 13 - Prob. 9SACh. 13 - Prob. 10SACh. 13 - Prob. 1CTCh. 13 - Prob. 2CTCh. 13 - Prob. 3CTCh. 13 - Prob. 4CTCh. 13 - Prob. 5CTCh. 13 - Prob. 6CTCh. 13 - Prob. 7CTCh. 13 - Why has it been difficult to develop a complete...Ch. 13 - Prob. 9CTCh. 13 - What differences would you expect in the...Ch. 13 - Prob. 11CTCh. 13 - Prob. 12CTCh. 13 - Prob. 13CTCh. 13 - Using the following terms, fill in the following...
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- Which of the following are the functions of reverse transcriptase in retroviruses? i) it hydrolyzes the host cell's DNA ii) it uses viral RNA as a template for DNA synthesis iii) it converts host cell RNA into viral DNA iv) it translates viral RNA into proteins v) It uses viral RNA as a template for making complementary RNA strand vi) It degrades RNA from DNA-RNA hybrid Oi, iv and v O ii, iv, v and vi ii and iii ii and viarrow_forwardThe RNA genomes of some RNA viruses resemble the messenger RNA (mRNA) of their eukaryotic hosts. What advantage would an RNA virus gain by having this type of genome?arrow_forwardRhinovirus and the flaviviruses have a _________ RNA genome, which ___________________ bind in order for translation to occur. As with most viruses with such genomes, they produce a ________________ (type of peptide), which is cleaved in order to produce the individual viral proteinsarrow_forward
- a. Which type of viruses can be directly used for translation? a) dsRNA b) Positive ssRNA c) Retroviruses d) Negative ssRNA b. An antiviral drug specifically modifies viral receptors on a eukaryotic host cell. How might this affect the viral reproductive cycle? It would enhance the process of viral apoptosis It would result in the degeneration of the viral capsid It would facilitate the process of viral endocytosis It would prevent the virus from attaching to the host cellarrow_forwardWhy do both hepadnaviruses and retroviruses requirereverse transcriptase when their genomes are doublestranded DNA and single-stranded RNA, respectively?arrow_forwardA viral particle adsorbs onto a host cell membrane. It uncoats and releases its single-stranded nonsegmented nucleic acid into the cytoplasm where it is immed dependent RNA polymerase, into mRNA. It is then translated into viral structural proteins and enzymes. Which of the following virus families is most likely repre A) Herpesviridae B) Paramyxoviridae C) Parvoviridae D) Reovirius E) Retroviridaearrow_forward
- Simian Virus 40 is carcinogenic in primates. 1). which molecule of the virus 2). what particular property of the molecule that enable the malignant transformation.arrow_forwardWhat kinds of enzymes can be found within the virions of RNAviruses? Why are they there?arrow_forwardCompare how retroviruses solve the problem of replicating an RNA genome in a eukaryotic host with how other types of RNA viruses solve this same problem.arrow_forward
- we can stop the biosynthesis stage of the viral life cycle (not the stages before it) by preventing/inhibiting: A) fusion of the envelope and the plasma membrane B) replication and expression of viral nucleic acid/genome C) the virus's attachment molecules from binding to the host cell receptor D) new copies of viral nucleic acid from combining with newly made viral proteins E)buddingarrow_forwardWhat is crystallization of a virus? What is the importance of this process?arrow_forwardThe diagrams below represent nucleic acid genomic material and a finished product after the viral polymerase acted on the genomic material. Name the virus (either family, genus, or particular virus is acceptable) that these diagrams represent. A is B is C is Dis Genomic material Product + sense RNA A 5' VPB -sense RNA 3' VPg 5' -sense RNA 5' cap Derived from infected cell B 3' 5' AAAAA(A) 3 + sense RNA C + sense RNA -sense RNA +sense RNA 5' 3'arrow_forward
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