Genetics: A Conceptual Approach 6E w/ SaplingPlus (Six-Month Access)
Genetics: A Conceptual Approach 6E w/ SaplingPlus (Six-Month Access)
6th Edition
ISBN: 9781319125929
Author: Benjamin A. Pierce
Publisher: W. H. Freeman
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Chapter 12.4, Problem 38CQ
Summary Introduction

To explain:

The way through which m-AMSA and other anticancer agents that target topoisomerase enzymes taking part in replication might lead to DNA breaks and chromosome rearrangements.

Introduction:

DNA topoisomerase plays an important role in replication and supercoilingof DNA double helix. Many anticancer drugs target topoisomerase enzyme. m-AMSA isan anticancer compound act on topoisomerase, was studied by Eric Nelson and his colleagues. m-AMSA stabilizes an intermediate, which is synthesized during actions of topoisomerase enzyme. Topoisomerase consisted by such intermediatebounds to the broken ends of DNA. m-AMSA, an anticancer compound causes breaks in DNA and stops the proliferation of cancer cells.

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