ANATOMY & PHYS VOL 2(CH 18-29) >CUSTOM<
9th Edition
ISBN: 9781307677720
Author: SALADIN
Publisher: MCG/CREATE
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Chapter 12.4, Problem 2AYLO
What an
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 12 Solutions
ANATOMY & PHYS VOL 2(CH 18-29) >CUSTOM<
Ch. 12.1 - What is a receptor? Give two examples of...Ch. 12.1 - Distinguish between the central and peripheral...Ch. 12.1 - Prob. 3BYGOCh. 12.1 - What the nervous and endocrine systems have in...Ch. 12.1 - Three fundamental functions of the nervous system;...Ch. 12.1 - Differences between the central nervous system...Ch. 12.1 - The autonomic nervous system and its two divisionsCh. 12.2 - Sketch a multipolar neuron and label its...Ch. 12.2 - Explain the differences between a sensory neuron,...Ch. 12.2 - Prob. 6BYGO
Ch. 12.2 - Prob. 7BYGOCh. 12.2 - Three fundamental physiological properties of...Ch. 12.2 - Prob. 2AYLOCh. 12.2 - Prob. 3AYLOCh. 12.2 - Prob. 4AYLOCh. 12.2 - Ways in winch neurons transport substances between...Ch. 12.3 - Prob. 8BYGOCh. 12.3 - Prob. 9BYGOCh. 12.3 - Prob. 10BYGOCh. 12.3 - Six kinds of neuroglia; the structure and...Ch. 12.3 - Prob. 2AYLOCh. 12.3 - Prob. 3AYLOCh. 12.3 - The regeneration of a damaged nerve fiber; the...Ch. 12.4 - Prob. 11BYGOCh. 12.4 - Prob. 12BYGOCh. 12.4 - Prob. 13BYGOCh. 12.4 - Prob. 14BYGOCh. 12.4 - Prob. 15BYGOCh. 12.4 - Prob. 16BYGOCh. 12.4 - Prob. 17BYGOCh. 12.4 - Prob. 1AYLOCh. 12.4 - What an electrical current is, and how sodium ions...Ch. 12.4 - How stimulation of a neuron generates a local...Ch. 12.4 - Prob. 4AYLOCh. 12.4 - Prob. 5AYLOCh. 12.4 - Prob. 6AYLOCh. 12.4 - Prob. 7AYLOCh. 12.4 - How one action potential triggers another; how the...Ch. 12.4 - Saltatory conduction in a myelinated nerve fiber,...Ch. 12.5 - Prob. 18BYGOCh. 12.5 - Prob. 19BYGOCh. 12.5 - Prob. 20BYGOCh. 12.5 - Prob. 21BYGOCh. 12.5 - Prob. 1AYLOCh. 12.5 - Prob. 2AYLOCh. 12.5 - Prob. 3AYLOCh. 12.5 - Prob. 4AYLOCh. 12.5 - Excitatory synapses; how acetylcholine and...Ch. 12.5 - Prob. 6AYLOCh. 12.5 - Prob. 7AYLOCh. 12.5 - Prob. 8AYLOCh. 12.5 - Prob. 9AYLOCh. 12.6 - Prob. 22BYGOCh. 12.6 - Prob. 23BYGOCh. 12.6 - Prob. 24BYGOCh. 12.6 - Contrast serial and parallel processing and...Ch. 12.6 - Prob. 26BYGOCh. 12.6 - Explain how long-term potentiation and long-term...Ch. 12.6 - Prob. 1AYLOCh. 12.6 - Prob. 2AYLOCh. 12.6 - Prob. 3AYLOCh. 12.6 - How a postsynaptic neurons decision to fire...Ch. 12.6 - Prob. 5AYLOCh. 12.6 - Mechanisms of presynaptic facilitation and...Ch. 12.6 - Prob. 7AYLOCh. 12.6 - Prob. 8AYLOCh. 12.6 - The meanings of neural pool and neural circuitCh. 12.6 - The difference between a neurons discharge zone...Ch. 12.6 - Diverging, converging, reverberating, and parallel...Ch. 12.6 - The difference between serial and parallel...Ch. 12.6 - The cellular basis of memory; what memory consists...Ch. 12.6 - Prob. 14AYLOCh. 12.6 - Prob. 15AYLOCh. 12 - The integrative functions of the nervous system...Ch. 12 - The highest density of voltage-gated ion channels...Ch. 12 - The soma of a mature neuron lacks a. a nucleus. b....Ch. 12 - The glial cells that fight infections in the CNS...Ch. 12 - Posttetanic potentiation of a synapse increases...Ch. 12 - An IPSP is_____of the postsynaptic neuron. a. a...Ch. 12 - Prob. 7TYRCh. 12 - Prob. 8TYRCh. 12 - Prob. 9TYRCh. 12 - Prob. 10TYRCh. 12 - Prob. 11TYRCh. 12 - Prob. 12TYRCh. 12 - Prob. 13TYRCh. 12 - Prob. 14TYRCh. 12 - Prob. 15TYRCh. 12 - A myelinated nerve fiber can produce action...Ch. 12 - Prob. 17TYRCh. 12 - Prob. 18TYRCh. 12 - Prob. 19TYRCh. 12 - Prob. 20TYRCh. 12 - Prob. 1BYMVCh. 12 - Prob. 2BYMVCh. 12 - Prob. 3BYMVCh. 12 - Prob. 4BYMVCh. 12 - Prob. 5BYMVCh. 12 - Prob. 6BYMVCh. 12 - Prob. 7BYMVCh. 12 - Prob. 8BYMVCh. 12 - Prob. 9BYMVCh. 12 - Prob. 10BYMVCh. 12 - Prob. 1WWTSCh. 12 - Prob. 2WWTSCh. 12 - Prob. 3WWTSCh. 12 - Prob. 4WWTSCh. 12 - Excitatory postsynaptic potentials lower the...Ch. 12 - Prob. 6WWTSCh. 12 - Prob. 7WWTSCh. 12 - Myelinated nerve fibers conduct signals more...Ch. 12 - Prob. 9WWTSCh. 12 - Prob. 10WWTSCh. 12 - Schizophrenia is sometimes treated with drugs such...Ch. 12 - Hyperkalemia is an excess of potassium ill the...Ch. 12 - Suppose a poison were to slow down the Na+-K+...Ch. 12 - Prob. 4TYCCh. 12 - Prob. 5TYC
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