EBK HUMAN ANATOMY
9th Edition
ISBN: 9780135241752
Author: Marieb
Publisher: PEARSON CO
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Chapter 12, Problem 7CYU
Which structural type of neuron is most abundant? Which neurons in the PNS are of this type?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 12 Solutions
EBK HUMAN ANATOMY
Ch. 12 - In which direction are afferent signals carried?...Ch. 12 - What subdivision of the nervous system regulates...Ch. 12 - What type of sensation is (a) pain from a pulled...Ch. 12 - Which type of neuron process receives stimuli?Ch. 12 - Describe how the electrical impulse from one...Ch. 12 - What is the structural type of most sensory...Ch. 12 - Which structural type of neuron is most abundant?...Ch. 12 - Which neuroglia make myelin in the CNS? In the...Ch. 12 - Which neuroglia are common in regions where...Ch. 12 - Do Schwann cells cover nonmyelinated axons in the...
Ch. 12 - Name the connective tissue wrapping that encloses...Ch. 12 - Where do synaspes occur in the CNS, in white...Ch. 12 - Why is white matter white?Ch. 12 - If there is no interneuron in a reflex arc, as in...Ch. 12 - If you touch a hot stove, you reflexively...Ch. 12 - What type of neuronal circuit contains multiple...Ch. 12 - Both peripheral nerves and the white matter of the...Ch. 12 - From your understanding of the functions of myelin...Ch. 12 - What type of neurons form from neuroblasts in the...Ch. 12 - How does the development of sensory neurons...Ch. 12 - Prob. 1RQCh. 12 - Match the names of the cells in column B with the...Ch. 12 - Prob. 3RQCh. 12 - Prob. 4RQCh. 12 - An example of an effector is (a) the eye, (b) a...Ch. 12 - Prob. 6RQCh. 12 - A ganglion is a collection of (a) neuron cell...Ch. 12 - A synapse between a terminal bouton and a neuron...Ch. 12 - Myelin is most like which of the following cell...Ch. 12 - Prob. 10RQCh. 12 - Afferent neurons of the PNS synapse in the CNS...Ch. 12 - Prob. 12RQCh. 12 - Prob. 13RQCh. 12 - Place the connective tissue coverings surrounding...Ch. 12 - Define proprioception.Ch. 12 - Prob. 16RQCh. 12 - Prob. 17RQCh. 12 - Distinguish gray matter from white matter of the...Ch. 12 - What is distinctive about the appearance of a cell...Ch. 12 - Describe the differences between neurons and...Ch. 12 - Distinguish a nerve from a nerve fiber and a...Ch. 12 - Prob. 22RQCh. 12 - Draw a reflex arc in place in the nervous system...Ch. 12 - Prob. 24RQCh. 12 - Why are the cell bodies of sensory neurons located...Ch. 12 - Prob. 26RQCh. 12 - Two anatomists were arguing about a sensory...Ch. 12 - An MRI scan and other diagnostic tests indicated...Ch. 12 - Prob. 3CRCAQCh. 12 - Rochelle developed multiple sclerosis when she was...Ch. 12 - Reflexes can be somatic (as in the knee-jerk...Ch. 12 - Prob. 6CRCAQ
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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