Excursions in Mathematics, Loose-Leaf Edition Plus MyLab Math with Pearson eText -- 18 Week Access Card Package
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Chapter 12, Problem 6E
To determine

The missing entries in the given table.

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In a crossover trial comparing a new drug to a standard, π denotes the probabilitythat the new one is judged better. It is desired to estimate π and test H0 : π = 0.5against H1 : π = 0.5. In 20 independent observations, the new drug is better eachtime.(a) Find and plot the likelihood function. Give the ML estimate of π (Hint: youmay use the plot function in R)
Q9. If A and B are two events, prove that P(ANB) ≥ 1 − P(Ā) – P(B). [Note: This is a simplified version of the Bonferroni inequality.] -
Can you explain what this analysis means in layman's terms?   - We calculated that a target sample size of 3626, which was based on anticipated baseline 90-day mortality of 22% and a noninferiority margin of no more than 4 percentage points, would give the trial 80% power, at a one-sided alpha level of 2.5%, accounting for a maximum of 5% loss to follow-up and for early stopping rules for three interim analyses.-

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Excursions in Mathematics, Loose-Leaf Edition Plus MyLab Math with Pearson eText -- 18 Week Access Card Package

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