Chapter 12, Problem 4P

(a)

Summary Introduction

To determine: How mutations in R and C subunit of $\text{cAMP}$ dependent protein kinase A (PKA) might lead to a constantly active PKA.

Introduction:

Mutation in an organism is defined as the alteration of “nucleotide sequences”. The mutations can be harmful, beneficial or neutral depending on the location of alteration in the genome and the effect on the environment.

(b)

Summary Introduction

To explain: How mutations in R and C subunit of $\text{cAMP}$ dependent protein kinase (PKA) might lead to a constantly inactive PKA.

Introduction:

Mutation in an organism is defined as the alteration of “nucleotide sequences”. The mutations can be harmful, beneficial or neutral depending on the location of alteration in the genome and the effect on the environment.