Concept explainers
Interpretation:
The affect of the replacement of tryptophan by cysteine to the
Concept introduction:
DNA stands for deoxyribonucleic acid, is a biological macromolecule. In organisms, it carries genetic information and is required for protein production, cell reproduction, regulation and metabolism.
There are four base types of DNA: adenine (A), cytosine (C), guanine (G) and thymine (T). The adenine is complementary nucleotide for thymine and cytosine is the complementary nucleotide for guanine.
Proteins are the biomolecules which are composed of the long chain of amino acid residues.

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- The graph displays the activities of wild-type and several mutated forms of subtilisin on a logarithmic scale. The mutations are identified as: • The first letter is the one-letter abbreviation for the amino acid being altered. • The number identifies the position of the residue in the primary structure. ⚫ The second letter is the one-letter abbreviation for the amino acid replacing the original one. • Uncat. refers to the estimated rate for the uncatalyzed reaction. Log₁(S-1) Wild type S221A H64A -5 D32A S221A H64A D32A -10 Uncat. How would the activity of a reaction catalyzed by a version of subtilisin with all three residues in the catalytic triad mutated compare to the activity of the uncatalyzed reaction? It would have more activity, because the reaction catalyzed by the triple mutant is approximately three-fold faster than the uncatalyzed reaction. It would have less activity, because the reaction catalyzed by the triple mutant is approximately 1000-fold slower than the…arrow_forwardB Substrate Product AL Product Substrate Reaction progress- Reaction progress- omplete the passage describing the two reactions. In reaction A, the stability of the substrate is (AG) of the reaction is positive, Incorrect Answer greater than the stability of the product. The free-energy change Incorrect Answer so the reaction is considered In reaction B, the stability of the substrate is (AG) of the reaction is less than Incorrect Answer endergonic and Incorrect Answer not spontaneous. Incorrect Answer the stability of the product. The free-energy change negative, so the reaction is considered Incorrect Answer exergonic and spontaneous. Incorrect Answer Incorrect Answerarrow_forwardMatch the descriptions and compounds with the terms competitive, uncompetitive, and noncompetitive inhibition. Competitive inhibition Uncompetitive inhibition Noncompetitive inhibition Answer Bank inhibitor binds to the enzyme-substrate complex only Vmax remains the same but Ky increases inhibitor and substrate can bind simultaneously lowers Vmax and KM doxycycline sulfanilamide KM remains unchanged, but Vis lower prevents substrate from binding to the active site Rounduparrow_forward
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- When was the dihydropyridine calcium channel blocker isradipine first patented and by whom? Please provide information on the origin and history of isradipine and who owns it/manufactures it.arrow_forward9) Below, there is a representation of an SDS-PAGE gel. Assuming the samples in the MW standard have masses of: 66 kDa, 45 kDa, 36 kDa, 29 kDa, 24 kDa, 20.1 kDa, and 14.2 kDa, a) Figure 4: indicate where each of the measurements were taken and label as in II.6. figure 2 above. b) As in II.7. Table 1 above create Table 2 using the data below. Determine the r.f. values for the MW standards, plot the relative mobility versus the log of the mass for the standards, and use the best fit straight line to determine the molecular weights of the proteins in the whey, peak 1, and peak 2 lanes. (5 pts—this will be scaled up appropriately if your gel did not develop properly) dye MW Whey Peak 1 Peak 2arrow_forwardwhat are the different classes and some examples of neuroprotectants that can be used to treat, prevent, or combat neurotoxicity/a neurotoxicant...for example, antioxidants, nutraceuticals, etc.,..?arrow_forward
- Imagine that aldolase can react with the seven carbon molecule Sedoheptulose-1,7-bisphosphate (below). Use the mechanism to predict the two products generated. Please draw out the stereochemistry in a fischer projection.arrow_forwardSodium borohydride (NaBH4) is a potent inhibitor of aldolase. It is known to ONLY inhibit theenzyme when it is complexed with substrate. Treatment of the enzyme alone has no effect.What is the mechanism for this inhibition? Please draw out the mechanism and show how it inhibits this.arrow_forwardShow the fate of the proton on the 4-Oxygen molecule of F-1,6-BP. Please include a drawing showing the electron flow that occurs.arrow_forward
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
