Biological Science (6th Edition)
Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 12, Problem 14PIAT

PROCESS OF SCIENCE Aggressive forms of breast cancer are resistant to Taxol chemotherapy. In these cancers, the gene encoding a protein called stathmin is overexpressed. To investigate the mechanism of action of stathmin, investigators measured tumor volume over time in mice with aggressive cancers under three conditions: no treatment (control), Taxol treatment, and Taxol treatment with stathmin gene expression turned off (Taxol+∆stathmin). Their results are shown below. Use these results to hypothesize how the stathmin protein affects microtubule stability.

Chapter 12, Problem 14PIAT, 14. PROCESS OF SCIENCE Aggressive forms of breast cancer are resistant to Taxol chemotherapy. In

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