Biological Science (6th Edition)
Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
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Chapter 12, Problem 11PIAT

The bark of the Pacific yew tree (Taxusbrevifolia) was the original source of one of the most effective drugs for treating tumors of the breast, lung, and other sites. Taxol, a chemical extracted from this bark, kills actively replicating cells by inhibiting the depolymerization of microtubules. Why are microtubules good targets for killing cancerous cells?

During what phases in the cell cycle would you expect there to be large changes in the polymerization or depolymerization of microtubules? Why are these changes necessary?

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