Campbell Biology In Focus, Loose-leaf Edition (3rd Edition)
3rd Edition
ISBN: 9780134895727
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky
Publisher: PEARSON
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Textbook Question
Chapter 12, Problem 10TYU
SCIENTIFIC INQUIRY
DRAW IT Assume you are mapping genes A, B, C, and D in Drosophila. You know that these genes are linked on the same chromosome, and you determine the recombination frequencies between each pair of genes to be as follows: A and B, 8%; A and C, 28%; A and D, 25%; 8 and C, 20%, B and D, 33%.
- a. Describe how you determined the recombination frequency for each pair of genes.
- b. Draw a chromosome map based on your data.
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Part A
You start your experiments with the eyeless mutation on chromosome IV. You cross the reciprocal translocation strain to the eyeless pure line to generate F, flies that are both translocation heterozygotes and Ee
heterozygotes. You decide to testcross F, males and females in two separate experiments to take advantage of the fact that crossing over does not occur in male Drosophila.
F, males x pure eyeless females (Note: There is no crossing over F, females x pure eyeless males (Note: Crossing over
in the F, males.)
Cross
may occur in the F, females.)
4 eyeless, fully fertile
4 wild-type, semi-sterile
4 eyeless, semi-sterile
4 wild-type, fully fertile
4 eyeless, fully fertile
4 wild-type, semi-sterile
4 eyeless, semi-sterile
4 wild-type, fully fertile
F, Progeny
What can you conclude from these results? Select the two correct statements.
> View Available Hint(s)
O The F2 progeny in both experiments contain recombinants.
O The F2 progeny contain recombinants only when F, females…
In a species of rat, the map unit distance between genes A, B, C and D were asfollows:
(in the picture)
(a) What is the order of these genes on the chromosome? (b) What is the map unit distance between B and D?
Chapter 12 Solutions
Campbell Biology In Focus, Loose-leaf Edition (3rd Edition)
Ch. 12.1 - Which one of Mendels laws relates to the...Ch. 12.1 - MAKE CONNECTIONS Review the description of meiosis...Ch. 12.1 - WHAT IF? Propose a possible reason that the first...Ch. 12.2 - A white-eyed female Drosophila is mated with a...Ch. 12.2 - Neither Tim nor Rhoda has Duchenne muscular...Ch. 12.2 - MAKE CONNECTIONS Consider what you learned about...Ch. 12.3 - When two genes are located on the same chromosome,...Ch. 12.3 - For each type of offspring of the testcross in...Ch. 12.3 - WHAT IF? Genes A, B, and C are located on the same...Ch. 12.4 - About 5% of individuals with Down syndrome have a...
Ch. 12.4 - WHAT IF? The ABO blood type locus has been mapped...Ch. 12.4 - MAKE CONNECTIONS The gene that is activated on the...Ch. 12.4 - Women born with an extra X chromosome (XXX) are...Ch. 12 - A man with hemophilia (a recessive, sex-linked...Ch. 12 - Pseudohypertrophic muscular dystrophy is an...Ch. 12 - A space probe discovers a planet inhabited by...Ch. 12 - Using the information from problem 3, scientists...Ch. 12 - A man with red-green color blindness (a recessive,...Ch. 12 - You design Drosophila crosses to provide...Ch. 12 - A wild-type fruit fly (heterozygous for gray body...Ch. 12 - Assume that genes A and B are 50 map units apart...Ch. 12 - Prob. 9TYUCh. 12 - SCIENTIFIC INQUIRY DRAW IT Assume you are mapping...Ch. 12 - FOCUS ON EVOLUTION Crossing over is thought to be...Ch. 12 - FOCUS ON INFORMATION The continuity of life is...Ch. 12 - SYNTHESIZE YOUR KNOWLEDGE Butterflies have an X-Y...
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- Imagine that you are mapping out genes on chromosomes similar to how Morgan did with fruit flies. You find gene A recombines with gene B 20% of the time, gene A recombines with gene C 5% of the time, and gene B and C recombine 17% of the time. Which gene is closest to gene B? A C Don't pick this one Don't pick this one eitherarrow_forwardIn an electrophoretic gel across which is applied a powerful electrical alternating pulsed field, the DNA of the haploid fungus Neurospora crassa (n = 7) moves slowly but eventually forms seven bands, which represent DNA fractions that are of different sizes and hence have moved at different speeds. These bands are presumed to be the seven chromosomes. How would you show which band corresponds to which chromosome?arrow_forwardIn the lab, you discover two yeast haploid mutants that cannot produce arginine. You cross them together and the resulting diploid produces arginine. If producing arginine is the wild type phenotype, what can you definitively conclude? A.The haploid strains have identical mutations in the same genes. B.The haploid strains have identical mutations in different genes. C.The haploid strains have mutations in different genes. D.The haploid strains have mutations in the same gene. E.The haploid strains must belong to the complementation group encoding the first enzyme in the biosynthetic pathway.arrow_forward
- Step 3: Compare the Parentals with the Double Cross Overs (DCO) to determine the correct order of the genes along the chromosome. A. List the alleles on the chromosome diagrams below. Parentals DCO B. Which single gene allele pair in the double cross over if exchanged would make the double cross over chromosomes be exactly like the Parentals? C. Reorder the alleles on the Parental chromosomes so that the gene allele pair in part B is in the middle. Check the order, by creating a double cross over of the Parental chromosomes. If alleles combination (not order) matches the DCO then you correctly determined which gene is in the middle for the chromosome map. Parentals Step 4: Rewrite all the gene orders in Step 2 in the space below with the correct gene in the middle.arrow_forwardThe mutations called bobbed in Drosophila result from variable reductions (deletions) in the number of amplified genes coding for rRNA. Researchers trying to maintain bobbed stocks have often documented their tendency to revert to wild type in successive generations. Propose a mechanism based on meiotic recombination which could account for this reversion phenomenon. Why would wild-type flies become more prevalent in Drosophila cultures?arrow_forwardGenes A and B are 7.5 map units apart on one chromosome. Genes C and D are 8.0 map units apart on a second non-homologous chromosome. • The recombination frequency between A and B is? • The recombination frequency between A and C is? • The recombination frequency between C and D is? • The recombination frequency between B and D is?arrow_forward
- Construct a genetic map using the following data: A line of drosophila has been constructed with three recessive mutations: sc = loss of thorax bristles ("scute") ec = roughened eye surface ("echinus") vg = vestigial wings The dominant, wild-type version of each allele could be written as vg + or ec+, but we will write them just as "+" for simplicity. P generation: We cross homozygous recessive flies (sc ec vg / sc ec vg) with homozygous dominant (wild-type) flies (+ + + / + + +). F1 generation: All of the flies produced by the parental cross have the dominant (wild-type) phenotype. Genetically, these flies are: (sc ec vg / + + + ). F2 generation: We produce an F2 generation by mating the F1 flies with homozygous recessive flies (sc ec vg / sc ec vg) This cross produces an F2 generation with 8 different phenotypes: All wild type features – 430 echinus – 5 echinus, vestigial – 29 scute – 25 scute, echinus – 44 scute, echinus, and vestigial – 417 scute,…arrow_forwardResearchers have discovered that some regions of chromosomes are more likely than others to cross over, these areas of frequent crossing over are called "recombination hot spots". Gene A and B are 500,000 bp apart - both genes and the space between them are in a recombination hot spot. Gene C and D are also 500,000 bp apart but the region containing genes C and D are not a recombination hot spot. Would the map distance between A and B be the same as the map distance between C and D? Explain your answer.arrow_forwardThe normal sequence of nine genes on a certainDrosophila chromosome is 123 • 456789, where the dotrepresents the centromere. Some fruit flies were foundto have aberrant chromosomes with the followingstructures:a. 123 • 476589 c. 1654 • 32789b. 123 • 46789 d. 123 • 4566789Name each type of chromosomal rearrangement, anddraw diagrams to show how each would synapse withthe normal chromosome.arrow_forward
- Is each of the following a method used in linkage, cytogenetic, orphysical mapping?A. Fluorescence in situ hybridization (FISH)B. Conducting two-factor crosses to compute map distancesC. Chromosome walkingD. Examination of polytene chromosomes in DrosophilaE. Use of RFLPs in crossesF. Using BACs and cosmids to construct a contigarrow_forwardMetacentric chromosomes have a centromere located: A. near the middle of the chromosome (chromosome has two arms of approx. equal length) B. towards one end (chromosome has one long arm and one short arm) C. near one end of the chromosome (chromosome has one long arm and a knob at the other end)arrow_forwardDeletions in bacterial chromosomes give the following data: Region of deletion Al Gene A activity +++ A2 АЗ A4 AS +++ (i) Where is the gene located? Explain your answer. Name the scientific term that describes the appearance of a recessive phenotype due to deletion of dominant gene. (ii) (iii) The phenotypic consequences of deletion depend on two factors. What are they? Give one example of human genetic disorder caused by chromosomal deletion by indicating the region of deletion in chromosome. (iv)arrow_forward
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