The Ura3 based selection identifies cells with defects in components required for import into the mitochondrial matrix. Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

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Answer 1

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Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 12, Problem 10P

Summary Introduction

To explain: The Ura3 based selection identifies cells with defects in components required for import into the mitochondrial matrix.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the normal cells with modified Ura3 gene doesn’t grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the cells that are defective for mitochondrial import grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

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Answer 2

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 12, Problem 10P

Summary Introduction

To explain: The Ura3 based selection identifies cells with defects in components required for import into the mitochondrial matrix.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the normal cells with modified Ura3 gene doesn’t grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the cells that are defective for mitochondrial import grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

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Answer 3

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 12, Problem 10P

Summary Introduction

To explain: The Ura3 based selection identifies cells with defects in components required for import into the mitochondrial matrix.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the normal cells with modified Ura3 gene doesn’t grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the cells that are defective for mitochondrial import grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

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Answer 4

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 12, Problem 10P

Summary Introduction

To explain: The Ura3 based selection identifies cells with defects in components required for import into the mitochondrial matrix.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the normal cells with modified Ura3 gene doesn’t grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the cells that are defective for mitochondrial import grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Expert Solution & Answer

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Answer 5

Chapter 12, Problem 10P

Summary Introduction

To explain: The Ura3 based selection identifies cells with defects in components required for import into the mitochondrial matrix.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the normal cells with modified Ura3 gene doesn’t grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Summary Introduction

To explain: The reason why the cells that are defective for mitochondrial import grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Answer 6

Chapter 12, Problem 10P

Summary Introduction

To explain: The Ura3 based selection identifies cells with defects in components required for import into the mitochondrial matrix.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Answer 7

Chapter 12, Problem 10P

Summary Introduction

To explain: The Ura3 based selection identifies cells with defects in components required for import into the mitochondrial matrix.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Answer 8

Summary Introduction

To explain: The reason why the normal cells with modified Ura3 gene doesn’t grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Answer 9

Summary Introduction

To explain: The reason why the normal cells with modified Ura3 gene doesn’t grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Answer 10

Summary Introduction

To explain: The reason why the cells that are defective for mitochondrial import grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Answer 11

Summary Introduction

To explain: The reason why the cells that are defective for mitochondrial import grow in the absence of uracil.

Concept introduction: Ura 3 gene is involved in pyrimidine biosynthesis. Ura 3 gene produces an enzyme called Orotidine 5'-phosphate decarboxylase. Orotidine 5'-phosphate decarboxylase catalyses the decarboxylation step of orotidine monophosphate (OMP) to give uridine monophosphate(UMP) during pyrimidine biosynthesis. Uracil biosynthesis occurs in the cytosol.

Answer 12

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Answer 15

Ch. 12 - Prob. 1P Ch. 12 - Prob. 2P Ch. 12 - Prob. 3P Ch. 12 - Prob. 4P Ch. 12 - Prob. 5P Ch. 12 - Prob. 6P Ch. 12 - Prob. 7P Ch. 12 - Prob. 8P Ch. 12 - Prob. 9P Ch. 12 - Prob. 10P

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