The reason has to be explained for the non-Zaitsev elimination product of 3-methylcyclohexene when trans-1-bromo-2-methylcyclohexane treats with base. Concept introduction: E 2 elimination: Alkyl halide forms an alkene from the abstraction of the proton from the β-carbon atom followed by elimination of the halogen in a single step. Saytzeff's Rule: It is elimination reaction in which the formation of olefin on most hindered or highly substituted position. Given information: The structure of the product is shown below,

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need help please and thanks dont understand only need help with C-F Learning Goal: As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT. The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7). Part A - Difference in binding free eenergies Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol. The margin of error is 2%. Part B - Compare difference in free energy to the thermal…

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Chapter 11.SE, Problem 66AP

Interpretation Introduction

Interpretation:

The reason has to be explained for the non-Zaitsev elimination product of 3-methylcyclohexene when trans-1-bromo-2-methylcyclohexane treats with base.

Concept introduction:

E₂ elimination:

Alkyl halide forms an alkene from the abstraction of the proton from the β-carbon atom followed by elimination of the halogen in a single step.

Saytzeff's Rule:
It is elimination reaction in which the formation of olefin on most hindered or highly substituted position.

Given information:

The structure of the product is shown below,

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need help please and thanks dont understand only need help with C-F Learning Goal: As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT. The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7). Part A - Difference in binding free eenergies Compute the difference in binding free energy (at a physiological temperature T=310 K) for the complexes. Provide the difference as a positive numerical expression with three significant figures in kJ/mol. The margin of error is 2%. Part B - Compare difference in free energy to the thermal…

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