ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
3rd Edition
ISBN: 9781264013470
Author: McKinley
Publisher: MCGRAW-HILL LEARNING SOLN.(CC)
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Chapter 11.8, Problem 23WDL
Summary Introduction
To determine:
The common actions of muscles in the anterior compartment of the forearm.
Concept introduction:
Muscles are soft tissues that help to provide motion and force to the body. It is found in the body of animals and humans. It is also responsible for maintaining and changing of posture, locomotion, and movement of internal organs such as the heart.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 11 Solutions
ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
Ch. 11.1 - LEARNING OBJECTIVE
1. Compare and contrast the...Ch. 11.1 - WHAT DID YOU LEARN?
1 What is the difference...Ch. 11.1 - LEARNING OBJECTIVE
2. Describe and differentiate...Ch. 11.1 - Which muscle is strongera pennate muscle or a...Ch. 11.1 - Prob. 3LOCh. 11.1 - What is the difference between an agonist and a...Ch. 11.2 - LEARNING OBJECTIVES
4. List the seven...Ch. 11.2 - LEARNING OBJECTIVE
5. Give examples of muscles...Ch. 11.2 - What are some words used in muscle names that...Ch. 11.2 - The gluteus maximus muscle gets its name from...
Ch. 11.3 - Prob. 6LOCh. 11.3 - Prob. 7LOCh. 11.3 - Prob. 6WDLCh. 11.3 - Prob. 7WDLCh. 11.3 - Prob. 8LOCh. 11.3 - Prob. 9LOCh. 11.3 - Which extrinsic eye muscles abduct the eye (move...Ch. 11.3 - Prob. 10LOCh. 11.3 - Prob. 11LOCh. 11.3 - Prob. 12LOCh. 11.3 - Prob. 9WDLCh. 11.3 - Prob. 10WDLCh. 11.3 - Prob. 13LOCh. 11.3 - Prob. 1WDTCh. 11.3 - List the four suprahyoid muscles, and describe a...Ch. 11.3 - Prob. 14LOCh. 11.3 - Which neck muscles extend the neck? Which neck...Ch. 11.4 - Prob. 15LOCh. 11.4 - Prob. 16LOCh. 11.4 - Which muscles form the erector spinae, and what...Ch. 11.5 - Prob. 17LOCh. 11.5 - Prob. 18LOCh. 11.5 - Prob. 2WDTCh. 11.5 - Prob. 14WDLCh. 11.5 - How is the diaphragm involved in respiration?Ch. 11.6 - LEARNING OBJECTIVES
19. List the four pairs of...Ch. 11.6 - Prob. 20LOCh. 11.6 - What are the main actions of the abdominal...Ch. 11.7 - Prob. 21LOCh. 11.7 - Prob. 22LOCh. 11.7 - Prob. 17WDLCh. 11.8 - Prob. 23LOCh. 11.8 - Prob. 18WDLCh. 11.8 - Prob. 24LOCh. 11.8 - Prob. 25LOCh. 11.8 - Prob. 19WDLCh. 11.8 - Identify the rotator cuff muscles, and describe...Ch. 11.8 - Prob. 26LOCh. 11.8 - Prob. 27LOCh. 11.8 - Prob. 3WDTCh. 11.8 - What are the muscles in the anterior compartment...Ch. 11.8 - Prob. 22WDLCh. 11.8 - Prob. 28LOCh. 11.8 - Prob. 29LOCh. 11.8 - Prob. 23WDLCh. 11.8 - What muscles in the posterior compartment move the...Ch. 11.8 - Prob. 30LOCh. 11.8 - Prob. 25WDLCh. 11.9 - Prob. 31LOCh. 11.9 - Prob. 32LOCh. 11.9 - Prob. 26WDLCh. 11.9 - Prob. 33LOCh. 11.9 - LEARNING OBJECTIVES
34. Describe the muscles of...Ch. 11.9 - Prob. 27WDLCh. 11.9 - Prob. 35LOCh. 11.9 - Prob. 36LOCh. 11.9 - Prob. 28WDLCh. 11.9 - Prob. 37LOCh. 11.9 - WHAT DO YOU THINK?
4 The extensor digitorum...Ch. 11.9 - Prob. 29WDLCh. 11 - Prob. 1DYBCh. 11 - Prob. 2DYBCh. 11 - _____ 3. When this large muscle contracts, the...Ch. 11 - Prob. 4DYBCh. 11 - Prob. 5DYBCh. 11 - _____ 6. The dorsal interossei muscles in the hand...Ch. 11 - Prob. 7DYBCh. 11 - Prob. 8DYBCh. 11 - Prob. 9DYBCh. 11 - Prob. 10DYBCh. 11 - Prob. 11DYBCh. 11 - Which muscles of facial expression do you use to...Ch. 11 - Distinguish between suprahyoid and infrahyoid...Ch. 11 - What is the effect of contracting the abdominal...Ch. 11 - What movements are possible at the glenohumeral...Ch. 11 - Identify the compartments of the arm (brachium),...Ch. 11 - Prob. 17DYBCh. 11 - Prob. 18DYBCh. 11 - What leg muscles allow a ballet dancer to rise up...Ch. 11 - Which muscles are responsible for foot inversion?Ch. 11 - Prob. 1CALCh. 11 - Prob. 2CALCh. 11 - Prob. 3CALCh. 11 - Prob. 4CALCh. 11 - Prob. 5CALCh. 11 - Prob. 1CSLCh. 11 - While training on the balance beam, Pat slipped...Ch. 11 - Prob. 3CSLCh. 11 - Why is it more difficult for Eric to lift a heavy...
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