BIOLOGY (LL)
BIOLOGY (LL)
5th Edition
ISBN: 9781264115495
Author: BROOKER
Publisher: MCG
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Chapter 11.4, Problem 3CC
Summary Introduction

To determine: The movement of primase in the lagging strand in figure 11.19.

Introduction: The process of formation of daughter strands from DNA strands is termed as replication of DNA. The enzyme RNA primer initiates the synthesis of daughter DNA strands from the template strand. The RNA primer is synthesized by an enzyme known as DNA primase. Two strands are synthesized by this enzyme. One is the leading strand while the other is the lagging strand.

Summary Introduction

To determine: Whether primase moves from left to right or from right to left.

Introduction: The process of formation of daughter strands from DNA strands is termed as replication of DNA. The enzyme RNA primer initiates the synthesis of daughter DNA strands from the template strand. The RNA primer is synthesized by an enzyme known as DNA primase. Two strands are synthesized by this enzyme. One is the leading strand while the other is the lagging strand.

Summary Introduction

To determine: The way in which primase must move after it is done making a primer and has to start making the next primer at a new location.

Introduction: The process of formation of daughter strands from DNA strands is termed as replication of DNA. The enzyme RNA primer initiates the synthesis of daughter DNA strands from the template strand. The RNA primer is synthesized by an enzyme known as DNA primase. Two strands are synthesized by this enzyme. One is the leading strand while the other is the lagging strand.

Summary Introduction

To determine: Whether primase has to hop from left to right or right to left direction.

Introduction: The process of formation of daughter strands from DNA strands is termed as replication of DNA. The enzyme RNA primer initiates the synthesis of daughter DNA strands from the template strand. The RNA primer is synthesized by an enzyme known as DNA primase. Two strands are synthesized by this enzyme. One is the leading strand while the other is the lagging strand.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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