Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 11.1, Problem 4AYP
Name four categories of cellular targets for physical and chemical agents.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 11 Solutions
Microbiology: A Systems Approach
Ch. 11.1 - Distinguish among the terms sterilization,...Ch. 11.1 - Prob. 2AYPCh. 11.1 - Prob. 3AYPCh. 11.1 - Name four categories of cellular targets for...Ch. 11.2 - Prob. 5AYPCh. 11.2 - Prob. 6AYPCh. 11.2 - Define thermal death time and thermal death point,...Ch. 11.2 - Prob. 8AYPCh. 11.2 - Prob. 9AYPCh. 11.2 - Identify advantages and disadvantages of cold...
Ch. 11.2 - Differentiate between the two types of radiation...Ch. 11.2 - Prob. 12AYPCh. 11.2 - Prob. 13AYPCh. 11.3 - Name the desirable characteristics of chemical...Ch. 11.3 - Discuss several different halogen agents and their...Ch. 11.3 - List advantages and disadvantages to the use of...Ch. 11.3 - Explain the mode of action of alcohols and their...Ch. 11.3 - Prob. 18AYPCh. 11.3 - Define the term surfactant, and explain this...Ch. 11.3 - Identify examples of some heavy metal control...Ch. 11.3 - Discuss the advantages and disadvantages of...Ch. 11.3 - Prob. 22AYPCh. 11 - Microbial control methods that kill/destroy...Ch. 11 - Sanitization is a process by which a. the...Ch. 11 - Prob. 3MCQCh. 11 - Prob. 4MCQCh. 11 - Prob. 5MCQCh. 11 - The primary mode of action of nonionizing...Ch. 11 - The most practical method of disinfecting...Ch. 11 - A chemical with sporicidal properties is a....Ch. 11 - Prob. 9MCQCh. 11 - Detergents are a. high-level germicides. b....Ch. 11 - Prob. 11TFCh. 11 - Prob. 12TFCh. 11 - Prob. 13TFCh. 11 - Prob. 14TFCh. 11 - Prob. 15TFCh. 11 - a.Precisely what is microbial death? b.Why does a...Ch. 11 - Prob. 2CTQCh. 11 - Prob. 3CTQCh. 11 - Tissue transplantation is a procedure that saves...Ch. 11 - Conduct additional research on the use of...Ch. 11 - From chapter 2, figure 2.20. Study this...Ch. 11 - Prob. 2VCCh. 11 - Using the words that follow, please create a...
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