Campbell Biology: Custom Edition
18th Edition
ISBN: 9781323717271
Author: Urry, Cain, Wasserman, Minorsky, Reece
Publisher: PEARSON C
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 11, Problem 2TYU
The activation of receptor tyrosinc kinases is characterized by
(A) dimeiization and phosphorylation.
(B) dimerization and IP3 binding.
(C) a phosphorylation cascade.
(D) GTP liydrolysis.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
1) Amino acids that contain hydroxyl groups in their R-groups can be phosphorylated during cellular signaling.
(a) What amino acids can be phosphorylated? (use the one letter amino acid abbreviations)
(b) Does phosphorylation turn a signaling protein “on” or “off”?
(c) Whatis the most common source of a phosphate used to phosphorylate a protein
(d) What enzyme type (or category of enzymes)removes phosphates from proteins?
3) Acetylcholine binds to a GPCR on heart muscle, making the heart beat more slowly.
The activated receptor stimulates a G protein, which opens a K+ channel in the
plasma membrane, as shown in Figure 1. Which of the following would enhance
this effect of the acetylcholine?
(a)
(b)
(c)
(d)
Figure 1
addition of a high concentration of a non-hydrolyzable analog of GTP
addition of a drug that prevents the a subunit from exchanging GDP for
GTP
mutations in the acetylcholine receptor that weaken the interaction
between the receptor and acetylcholine
mutations in the acetylcholine receptor that weaken the interaction
between the receptor and the G protein
(a) Predict the effect of a mutation that enhances the activity of the kinase associated with the PDH complex. (b) Predict the effect of a mutation that reduces the activity of the phosphatase associated with the PDH complex.
Chapter 11 Solutions
Campbell Biology: Custom Edition
Ch. 11.1 - Explain how signaling is involved in ensuring that...Ch. 11.1 - In liver cells, glycogen Phosphorylase acts in...Ch. 11.1 - Prob. 3CCCh. 11.2 - Nerve growth factor (NGF) is a water-soluble...Ch. 11.2 - WHAT IF? What would the effect be if a cell made...Ch. 11.2 - MAKE CONNECTIONS How is ligand binding similar to...Ch. 11.3 - What is a protein kinase, and what is its role in...Ch. 11.3 - When a signal transduction pathway involves a...Ch. 11.3 - What is the actual signal that is being transduced...Ch. 11.3 - WHAT IF? If you exposed a cell to a ligand that...
Ch. 11.4 - How can a targct cell's response to a single...Ch. 11.4 - WHAT IF? If two cells have different scaffolding...Ch. 11.4 - Prob. 3CCCh. 11.5 - Give an example of apoptosis during embryonic...Ch. 11.5 - WH AT IF? If apoptosis occurred when it should...Ch. 11 - What determines whether a cell responds to a...Ch. 11 - How are the structures of a GPCR and an RTK...Ch. 11 - What is the difference between a protein kinase...Ch. 11 - What mechanisms in the cell terminale its response...Ch. 11 - What is an explanation for the similarities...Ch. 11 - Binding of a signaling molecule to which type of...Ch. 11 - The activation of receptor tyrosinc kinases is...Ch. 11 - Lipid-soluble signaling molecules, such as...Ch. 11 - Consider this pathway: epinephrine G...Ch. 11 - Apoptosis involves all but which of the following?...Ch. 11 - Which Observation suggestcd to Sutherland the...Ch. 11 - Protein phosphorylation is commonly involved with...Ch. 11 - DRAW IT Draw the following apoptotic pathway,...Ch. 11 - EVOLUTION CONNECTION Identify the evolutlonary...Ch. 11 - Prob. 10TYUCh. 11 - SCIENCE, TECHNOLOGY, AND SOCIETY The aging process...Ch. 11 - WRITE ABOUT A THEME: ORGANIZATION The properties...Ch. 11 - SYNTHESIZE YOUR KNOWLEDGE There are five basic...
Additional Science Textbook Solutions
Find more solutions based on key concepts
To test your knowledge, discuss the following topics with a study partner or in writing ideally from memory. Th...
HUMAN ANATOMY
Describe the role and impact of microbes on the earth.
Microbiology Fundamentals: A Clinical Approach
On what molecule does the anticodon appear? Explain the role of this molecule in protein synthesis.
Human Physiology: An Integrated Approach (8th Edition)
An obese 55-year-old woman consults her physician about minor chest pains during exercise. Explain the physicia...
Biology: Life on Earth with Physiology (11th Edition)
Choose the best answer to each of the following. Explain your reasoning. If Earth were twice as far as it actua...
Cosmic Perspective Fundamentals
4. 38 Strontium has four naturally occurring isotopes, with mass numbers 84, 86, 87, arid 88.
a. Write the atom...
General, Organic, and Biological Chemistry: Structures of Life (5th Edition)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium. They have an important role in vascular homeostasis. Endothelin activates G protein-coupled receptors (GPCRs) ETA or ETB on a target cell. Which subunit of heterotrimeric G protein is released when the receptor is activated? a.) gamme b.) beta c.) alphaarrow_forwardCompare and contrast GPCR and RTK receptors with respect to (a)structure (especially the transmembrane region), (b) activation mechanism, and (c) initial signal transduction across the membrane.arrow_forwardActivation of certain GPCRs triggers an intracellular signaling mechanism that involves activation of adenlyl cyclase and an increase of cAMP. Which of the following statements best describes the the events that follow such a cAMP increase? a.) The cAMP increase leads to activation of protein kinase C. b.) The cAMP increase leads to activation of the release of the gamma subunit from the GPCR. c.) The cAMP increase leads to activation of protein kinase A.arrow_forward
- A GRK inhibitor would have what effect on GPCR inactivation in the presence of a GPCR agonist? (a) it would decrease it; (b) it would maintain the same rate of inactivation; (c) it would increase it.arrow_forwardUpon activation by a receptor, a G protein exchanges bound GDP for GTP, rather than phosphorylating GDP that is already bound. Similarly, the a subunit-GTP complex has a slow GTPase activity that hydrolyzes bound GTP, rather than exchanging it for GDP. Describe experimental evidence that would be consistent with these conclusions.arrow_forwardWhen the _________ of G-protein is bound to ___________, it binds and activates the intracellular protein Adenylyl cyclase. a. alpha subunit ....... GTP b. gamma subunit ....... GTP c. alpha subunit ....... GDP d. gamma subunit ....... GDParrow_forward
- You perform a competition study on a GPCR. You have isolated the plasma membrane from cells which contains the GPCR of interest. If an agonist and an inverse agonist are at equal concentrations in your study but the inverse agonist has a 10 x higher affinity for the receptor than the agonist, what would you expect to be the overall outcome to be? More of the agonist is bound and so most of the receptor is in its active conformation and is stimulated More of the inverse agonist is bound and so most of the receptor is in its inactive conformation and is unstimulated.arrow_forwardEach adenylyl cyclase molecule produces many cAMP molecules in an example of (a) receptor up-regulation (b) receptor down-regulation (c) signal amplification (d) scaffolding (e) similarities produced by evolutionarrow_forwardThere is a relatively high concentration of phosphatidylcholine on the lumenal side of the ER membrane. What feature of membranes is responsible for this effect?arrow_forward
- What are the three steps by which receptor tyrosine kinases typically convey an extracellular signal to another intracellular enzyme?arrow_forwardH e l parrow_forwardWhich statement is TRUE regarding the Na+ voltage-gated channel in neurons? A) Similar to the potassium ion channel, it exists as a tetramer in the membrane. B) Aspartate residues are part of the voltage-sensing helices. C) Positive membrane potentials on the extracellular side will close the channel. D) Ion specificity comes from the voltage-sensing helices.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Biology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Biology (MindTap Course List)
Biology
ISBN:9781337392938
Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Immune System and Immune Response Animation; Author: Medical Sciences Animations;https://www.youtube.com/watch?v=JDdbUBXPKc4;License: Standard YouTube License, CC-BY
Immune response: summary; Author: Dr Bhavsar Biology;https://www.youtube.com/watch?v=ADANgHkX4OY;License: Standard Youtube License