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EBK HUMAN ANATOMY & PHYSIOLOGY
16th Edition
ISBN: 8220100659836
Author: AMERMAN
Publisher: PEARSON
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Chapter 11, Problem 2CYU
Summary Introduction
To review:
The overall effect on action potential when a drug inhibits the K+ (potassium ions) channels.
Introduction:
The sequential depolarization and repolarization of a cell contribute toward an action potential, which is primarily governed by two voltage-gated channels, namely, K+ channels/potassium ion channels and Na+ channels/sodium ion channels. The opening and closing of these channels determine the precise state of cellular excitability.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 11 Solutions
EBK HUMAN ANATOMY & PHYSIOLOGY
Ch. 11.1 - What are the organs of the CNS?Ch. 11.1 - Prob. 2QCCh. 11.1 - Describe the sensory, integrative, and motor...Ch. 11.1 - 4. What are the differences between the somatic...Ch. 11.1 - How does the somatic motor division of the PNS...Ch. 11.2 - What are the functions of the cell body,...Ch. 11.2 - What are the structural differences between...Ch. 11.2 - What are the functional differences between...Ch. 11.2 - What are the functions of astrocytes?Ch. 11.2 - Prob. 5QC
Ch. 11.2 - Prob. 6QCCh. 11.2 - 7. What is the function of the myelin sheath?
Ch. 11.2 - How does the myelin sheath differ in the CNS and...Ch. 11.2 - Are neurons more likely to regenerate in the CNS...Ch. 11.2 - Prob. 10QCCh. 11.3 - 1. What is the resting membrane potential?
Ch. 11.3 - Prob. 2QCCh. 11.3 - What two factors generate the resting membrane...Ch. 11.3 - Prob. 4QCCh. 11.3 - Prob. 5QCCh. 11.3 - In and around the axon, where is the higher...Ch. 11.3 - What is the resting membrane potential, and what...Ch. 11.3 - Prob. 8QCCh. 11.3 - Prob. 9QCCh. 11.3 - Prob. 10QCCh. 11.3 - What takes place during the depolarization phase...Ch. 11.3 - 7. What must be reached in order for...Ch. 11.3 - 8. What takes place during the repolarization and...Ch. 11.3 - 9. What are the absolute and relative refractory...Ch. 11.3 - 10. How do local potentials and action potentials...Ch. 11.3 - Which is useful for long-distance signaling, and...Ch. 11.3 - 12. How is an action potential propagated down an...Ch. 11.3 - Prob. 18QCCh. 11.4 - What are three locations where presynaptic axons...Ch. 11.4 - Define synaptic transmission.Ch. 11.4 - Prob. 3QCCh. 11.4 - Prob. 4QCCh. 11.4 - Prob. 5QCCh. 11.4 - Prob. 6QCCh. 11.4 - Prob. 7QCCh. 11.5 - Prob. 1QCCh. 11.5 - Prob. 2QCCh. 11.5 - Prob. 3QCCh. 11.5 - Prob. 4QCCh. 11.5 - Prob. 5QCCh. 11.6 - 1. Why are neurons organized into neuronal...Ch. 11.6 - Prob. 2QCCh. 11.6 - 3. What mechanisms stabilize neural circuits?
Ch. 11 - Which of the following statements about the...Ch. 11 - 2. Regulation of heart rate, blood pressure, and...Ch. 11 - Match each type of neuroglial cell with its...Ch. 11 - Prob. 4CYRCh. 11 - Prob. 5CYRCh. 11 - Prob. 6CYRCh. 11 - 7. Fill in the blanks: The _______is the period of...Ch. 11 - With respect to the condition of action...Ch. 11 - 9. Identify the following as properties of...Ch. 11 - The trigger for exocytosis of synaptic vesicles...Ch. 11 - Match the following neurotransmitters with their...Ch. 11 - 12. Which of the following is not a method by...Ch. 11 - 13. A ________is characterized by multiple input...Ch. 11 - Mark the following statements as true or false. If...Ch. 11 -
15. Mark the following statements as true or...Ch. 11 - Sequence the following list of events of a...Ch. 11 - 16. Mark the following statements as true or...Ch. 11 - 1. A drug that blocks channels in neurons does so...Ch. 11 - Prob. 2CYUCh. 11 - What conditions must be met for an axon to...Ch. 11 - 4. Explain how an action potential is propagated...Ch. 11 - Prob. 1AYKACh. 11 - 2. During a surgical procedure, an...Ch. 11 - Albert accidentally ingests the poison...Ch. 11 - 4. Albert, the patient in question 3, takes the...Ch. 11 - Predict the effect that tetrodotoxin would have on...Ch. 11 - Explain what would happen if depolarization of the...
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