Chapter 11, Problem 2CS

Summary Introduction

To determine:

Why the tissues that are derived from the rapidly dividing cells are initially affected.

Introduction:

Dyskeratosis congenita (DKC) is one of the rare inherited syndrome that affects telomeres. The disorder is associated with the mutations that occur in the protein subunits of the enzyme telomerase. The enzyme telomerase is responsible for the replication of the eukaryotic chromosomal ends. The initial symptoms occur in the tissues that are derived from the rapidly dividing cells, which includes bone marrow, skin, and nails.