Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 11, Problem 11PDQ
What was the significance of the polA1 mutation?
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*Example 2: Tracing the path of an autosomal dominant trait
Trait: Neurofibromatosis
Forms of the trait:
The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein
neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous
tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a
cancerous form. i
The recessive form is a normal protein - in other words, no neurofibromatosis.moovi
A typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not
indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis
allele, and the letter "n" for the normal allele.
Nn
nn
nn
2
nn
Nn
A
3
N-
Chapter 11 Solutions
Concepts of Genetics (11th Edition)
Ch. 11 - In the Meselson-Stahl experiment, which of the...Ch. 11 - An alien organism was investigated. When DNA...Ch. 11 - A researcher was asked if his work on the genetic...Ch. 11 - A researcher was asked if his work on the genetic...Ch. 11 - A researcher was asked if his work on the genetic...Ch. 11 - Prob. 4CSCh. 11 - HOW DOWE KNOW? In this chapter, we focused on how...Ch. 11 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 11 - Compare conservative, semiconservative, and...Ch. 11 - Describe the role of 15N in the MeselsonStahl...
Ch. 11 - Predict the results of the experiment by Taylor,...Ch. 11 - What are the requirements for in vitro synthesis...Ch. 11 - In Kornbergs initial experiments, it was rumored...Ch. 11 - How did Kornberg assess the fidelity of DNA...Ch. 11 - Which characteristics of DNA polymerase I raised...Ch. 11 - Kornberg showed that nucleotides are added to the...Ch. 11 - What was the significance of the polA1 mutation?Ch. 11 - Summarize and compare the properties of DNA...Ch. 11 - List and describe the function of the ten subunits...Ch. 11 - Distinguish between (a) unidirectional and...Ch. 11 - List the proteins that unwind DNA during in vivo...Ch. 11 - Define and indicate the significance of (a)...Ch. 11 - Outline the current model for DNA synthesis.Ch. 11 - Why is DNA synthesis expected to be more complex...Ch. 11 - Suppose that E. coli synthesizes DNA at a rate of...Ch. 11 - Several temperature-sensitive mutant strains of E....Ch. 11 - While many commonly used antibiotics interfere...Ch. 11 - Prob. 22PDQCh. 11 - Many of the gene products involved in DNA...Ch. 11 - In 1994, telomerase activity was discovered in...Ch. 11 - The genome of D. melanogaster consists of...Ch. 11 - Prob. 26ESPCh. 11 - DNA polymerases in all organisms add only 5...Ch. 11 - Prob. 28ESPCh. 11 - Assume that the sequence of bases shown below is...Ch. 11 - Prob. 30ESPCh. 11 - Reiji and Tuneko Okazaki conducted a now classic...Ch. 11 - Prob. 32ESPCh. 11 - Consider the drawing of a dinucleotide below. (a)...Ch. 11 - To gauge the fidelity of DNA synthesis, Arthur...
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