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Nursing Student with Neuropathic Pain
Tamara Costa broke her right tibia and has undergone two separate surgeries to repair it. Although the bone has healed, she suffers increasing pain around the incision sites. The painful area covers the lateral surface of her right leg. She can't stand wearing anything over it or even having a sheet touch it. Her diagnosis is postsurgical neuropathic pain. Pain medication has not helped.
Tamara is a second-year nursing student and has done some reading to try to understand her problem and perhaps find a solution. She has found an article that says neuropathic pain may be caused by a decreased threshold for action potential generation in pain-detecting neurons. However, she has forgotten some of her physiology and needs some help in understanding what she is reading. She has logged into the “Ask a Nurse" chat line–and she got you!
2. Tamara wants to know how a decrease in threshold in pain-detecting neurons would affect their firing. Draw a graph of an intracellular recording of a neuron showing the response to a below-threshold and an above-threshold stimulus. Then, using this graph, show how decreasing the threshold could lead to additional action potentials.
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Chapter 11 Solutions
EP HUMAN ANAT.+PHYS.LAB.MAN...-ACCESS
- calculate the questions showing the solution including variables,unit and equations all the questiosn below using the data a) B1, b) B2, c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim g) k10 h) k12 i) k21 j) initial concentration (C0) k) central compartment volume (V1) l) steady-state volume (Vss) m) clearance (CL) AUC (0→10 min) using trapezoidal rule n) AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞) p) total AUC (using short cut method) q) volume from AUC (VAUC)arrow_forwardQUESTION 8 For the following pedigree, assume that the mode of inheritance is X-linked recessive, and that the trait has full penetrance and expressivity and occurs at a very low frequency in the hum population. Using XA for the dominant allele and Xa for the recessive allele, assign genotypes for the following individuals (if it is not possible to figure out the second allele of a genotype, that with an underscore): 2 m 1 2 1 2 4 5 6 7 8 9 IV 1 2 3 5 6 7 8 CO 9 10 12 13 V 1, 2 3 4 5 6 7 8 9 10 11 12 13 a. Il-1: b. 11-2: c. III-3: d. III-4: e. If individuals IV-11 and IV-12 have another child, what is the probability that they will have a boy with the disorder?arrow_forwardAnswerrarrow_forward
- please,show workings ahd solutions calculate the questions showing the solution including variables,unit and equations all the questiosn below using the data a) B1, b) B2, c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim g) k10 h) k12 i) k21 j) initial concentration (C0) k) central compartment volume (V1) l) steady-state volume (Vss) m) clearance (CL) AUC (0→10 min) using trapezoidal rule n) AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞) p) total AUC (using short cut method) q) volume from AUC (VAUC)arrow_forwardQuestion about consensus and the relationship to transcriptional activityarrow_forwardQuestion about archaea and eukaryotic general transcription homologsarrow_forward
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- O Macmillan Learning You have 0.100 M solutions of acetic acid (pKa = 4.76) and sodium acetate. If you wanted to prepare 1.00 L of 0.100 M acetate buffer of pH 4.00, how many milliliters of acetic acid and sodium acetate would you add? acetic acid: mL sodium acetate: mLarrow_forwardHow does the cost of food affect the nutritional choices people make?arrow_forwardBiopharmaceutics and Pharmacokinetics:Two-Compartment Model Zero-Order Absorption Questions SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q a) B1, b) B2, c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim g) k10 h) k12 i) k21 j) initial concentration (C0) k) central compartment volume (V1) l) steady-state volume (Vss) m) clearance (CL) AUC (0→10 min) using trapezoidal rule n) AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞) p) total AUC (using short cut method) q) volume from AUC (VAUC)arrow_forward
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