Essentials of Human Anatomy and Physiology (Custom)
15th Edition
ISBN: 9781269752862
Author: Marieb
Publisher: PEARSON
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Chapter 11, Problem 28SAE
Describe the structure of capillary walls.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 11 Solutions
Essentials of Human Anatomy and Physiology (Custom)
Ch. 11 - More than one choice may apply. Pulmonary veins...Ch. 11 - Given a volume of 150 ml at the end of diastole, a...Ch. 11 - Which of the following depolarizes next after the...Ch. 11 - More than one choice may apply. During atrial...Ch. 11 - More than one choice may apply. Isovolumetric...Ch. 11 - Soon after the onset of ventricular systole, the...Ch. 11 - The base of the heart is its ______ surface. a....Ch. 11 - 8. In comparing a parallel artery and vein, you...Ch. 11 - Prob. 9MCCh. 11 - Prob. 10MC
Ch. 11 - Prob. 11MCCh. 11 - 12. Which layer of the artery wall thickens most...Ch. 11 - Prob. 13MCCh. 11 - Prob. 14MCCh. 11 - The most external part of the pericardium is the...Ch. 11 - Prob. 16MCCh. 11 - Prob. 17MCCh. 11 - Prob. 18MCCh. 11 - 19. Draw a diagram of the heart showing the three...Ch. 11 - Prob. 20SAECh. 11 - Prob. 21SAECh. 11 - 22. Define systole and diastole.
Ch. 11 - Prob. 23SAECh. 11 - Prob. 24SAECh. 11 - Identify the components of the intrinsic...Ch. 11 - 26. Name three different factors that increase...Ch. 11 - Prob. 27SAECh. 11 - Describe the structure of capillary walls.Ch. 11 - Prob. 29SAECh. 11 - Name three factors that are important in promoting...Ch. 11 - Prob. 31SAECh. 11 - What are pre-capillary sphincters and vascular...Ch. 11 - Prob. 33SAECh. 11 - 34. In a fetus, the liver and lungs are almost...Ch. 11 - Explain why we are able to detect pulses at...Ch. 11 - Prob. 36SAECh. 11 - Prob. 37SAECh. 11 - 38. Two elements determine blood pressure—the...Ch. 11 - Prob. 39SAECh. 11 - Prob. 40SAECh. 11 - Prob. 41SAECh. 11 - Explain why blood flow in arteries is pulsatile...Ch. 11 - Explain the relationship between the...Ch. 11 - 44. Which type of blood vessel is most important...Ch. 11 - John is a 30-year-old man who is overweight and...Ch. 11 - 47. Mrs. Hamad, a middle-aged woman, is admitted...Ch. 11 - Hannah, a 14-year-old girl undergoing a physical...Ch. 11 - Prob. 48CAQCh. 11 - Stuart, a 49-year-old man, has been diagnosed with...Ch. 11 - Mr. Grimaldi was previously diagnosed as having a...Ch. 11 - Prob. 51CAQCh. 11 - The guards at the royal palace in London stand at...
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