Chapter 11, Problem 23P

A partial sequence of the wild-type Hbβ^A allele is shown here (the top strand is the RNA-like coding strand, and the location of the disease-causing mutation is underlined):

and the sickle-cell allele HBβ sequence is:

Design two 21-nucleotide-long ASOs that could be attached to a silicon chip for the microarray analysis performed in Problem 22. Two possibilities exist for each ASO; you only need to show one possibility for each.