Foundations in Microbiology
9th Edition
ISBN: 9780073522609
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 1.1, Problem 1ELO
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
Foundations in Microbiology
Ch. 1.1 - Define microbiology and microorganisms, and...Ch. 1.1 - Name and define the primary fields included in...Ch. 1.1 - Define what is meant by the term microorganism and...Ch. 1.1 - Describe five different ways in which humans...Ch. 1.2 - Prob. 3ELOCh. 1.2 - Prob. 4ELOCh. 1.2 - Prob. 5ELOCh. 1.2 - Prob. 3CYPCh. 1.2 - Observe figure 1.3 and place the microbes pictured...Ch. 1.2 - Prob. 5CYP
Ch. 1.2 - Prob. 6CYPCh. 1.3 - Prob. 6ELOCh. 1.3 - Describe several ways the beneficial qualities of...Ch. 1.4 - Prob. 7ELOCh. 1.4 - Prob. 8ELOCh. 1.4 - Prob. 8CYPCh. 1.4 - Prob. 9CYPCh. 1.5 - Prob. 9ELOCh. 1.5 - Prob. 10ELOCh. 1.5 - Prob. 10CYPCh. 1.5 - Prob. 11CYPCh. 1.5 - Prob. 12CYPCh. 1.5 - Why was the abandonment of the spontaneous...Ch. 1.6 - Define taxonomy and its supporting terms...Ch. 1.6 - Prob. 12ELOCh. 1.6 - Describe the goals of nomenclature and how the...Ch. 1.6 - Prob. 14CYPCh. 1.6 - Prob. 15CYPCh. 1.6 - Explain the binomial system of nomenclature and...Ch. 1.6 - Explain sonic of the benefits of using scientific...Ch. 1.7 - Prob. 14ELOCh. 1.7 - Explain the concepts behind the organization of...Ch. 1.7 - Explain the bases foe classification, taxonomy,...Ch. 1.7 - Prob. 17ELOCh. 1.7 - Prob. 18CYPCh. 1.7 - Prob. 19CYPCh. 1.7 - Prob. 20CYPCh. 1.7 - Archaea are often found living in extreme...Ch. 1.7 - Compare the domain system with the five-kingdom...Ch. 1.L1 - Which of the following is not considered a...Ch. 1.L1 - An area of microbiology that is concerned with the...Ch. 1.L1 - Which process involves the deliberate alteration...Ch. 1.L1 - A prominent difference between prokaryotic and...Ch. 1.L1 - Prob. 5MCQCh. 1.L1 - Abiogenesis refers to the a. spontaneous...Ch. 1.L1 - Prob. 7MCQCh. 1.L1 - Prob. 8MCQCh. 1.L1 - Which scientist is most responsible for finally...Ch. 1.L1 - Prob. 10MCQCh. 1.L1 - Prob. 11MCQCh. 1.L1 - Prob. 12MCQCh. 1.L1 - Prob. 13MCQCh. 1.L1 - Prob. 14MCQCh. 1.L1 - Prob. 15MCQCh. 1.L1 - Prob. 16MCQCh. 1.L1 - Prob. 1CSRCh. 1.L1 - Prob. 2CSRCh. 1.L1 - Prob. 3CSRCh. 1.L1 - What does it mean to say microbes are ubiquitous?Ch. 1.L1 - Prob. 2WCCh. 1.L1 - What events, discoveries, or inventions were...Ch. 1.L1 - Prob. 4WCCh. 1.L1 - Explain how microbes arc classified into groups...Ch. 1.L1 - Prob. 6WCCh. 1.L2 - What do you suppose the world would be like if...Ch. 1.L2 - How would you describe the types of scientific...Ch. 1.L2 - Give the technical name of a microbiologist who...Ch. 1.L2 - Name the six most common infectious agents on...Ch. 1.L2 - Prob. 5CTCh. 1.L2 - Prob. 6CTCh. 1.L2 - Prob. 7CTCh. 1.L2 - Construct the scientific name of a newly...Ch. 1.L2 - Prob. 1VC
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