BROOKER BIOLOGY
5th Edition
ISBN: 9781307656152
Author: BROOKER
Publisher: MCG/CREATE
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Chapter 1.1, Problem 1CC
At which level of
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Outline a method for using apomixis to maintain feminized CannabisAssume apomixis is controlled by a single dominant gene. You can choose the type of apomixis: obligate or facultative, gametophytic or sporophytic. Discuss advantages and disadvantages of your proposed method.
Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
BROOKER BIOLOGY
Ch. 1.1 - At which level of biological organization would...Ch. 1.3 - What is the relationship between biological...Ch. 1.3 - How does the concept of a tree of life differ from...Ch. 1.3 - Biologists sometimes say that the genome is the...Ch. 1.4 - Figure 1.10 The three domains of life. Two of...Ch. 1.4 - Why is it useful to place organisms into taxonomic...Ch. 1.5 - What is the purpose of a control group in...Ch. 1.5 - Explain how discovery-based science helped...Ch. 1.6 - Discuss the difference between discovery-based...Ch. 1.6 - What are the steps in the scientific method, also...
Ch. 1.6 - Prob. 3EQCh. 1.6 - Prob. 1CSCh. 1.6 - Core Skill: Modeling This modeling challenge asks...Ch. 1 - Which of the following is not a core concept of...Ch. 1 - Populations of organisms change over the course of...Ch. 1 - Prob. 3TYCh. 1 - Which of the following is an example of horizontal...Ch. 1 - The scientific name for humans is Homo sapiens....Ch. 1 - The complete genetic makeup of an organism a....Ch. 1 - Prob. 7TYCh. 1 - Prob. 8TYCh. 1 - Prob. 9TYCh. 1 - What is the purpose of using a control group in a...Ch. 1 - Of the five core concepts of biology described in...Ch. 1 - Explain how it is possible for evolution to result...Ch. 1 - Prob. 3CQCh. 1 - Discuss whether or not you think that theories in...Ch. 1 - Prob. 2COQ
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