Anatomy and Physiology by OpenStax
17th Edition
ISBN: 9781506698021
Author: J. Gordon Betts;Dean H. Kruse;Kelly A. Young;Peter DeSaix;Brandon Poe;Oksana Korol;James A. Wise;Eddie Johnson;Jody E. Johnson;Mark Womble
Publisher: XANEDU PUBLISHING
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Textbook Question
Chapter 11, Problem 18RQ
Which muscle pair plays a role in respiration?
- intertransversarii, interspinales
- semispinalis cervicis, semispinalis thoracis
- trapezius, rhomboids
- diaphragm, scalene
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 11 Solutions
Anatomy and Physiology by OpenStax
Ch. 11 - Which of the following is unique to the muscles of...Ch. 11 - Which of the following helps an agonist work? a...Ch. 11 - Which of the following statements is correct about...Ch. 11 - Which is moved the least during muscle...Ch. 11 - Which muscle has a convergent pattern of...Ch. 11 - A muscle that has a pattern of fascicles running...Ch. 11 - Which arrangement best describes a bipennate...Ch. 11 - The location of a muscles insertion and origin can...Ch. 11 - Where is the temporalis muscle located? on the...Ch. 11 - Which muscle name does not make sense? extensor...
Ch. 11 - Which of the following terms would be used in the...Ch. 11 - Which of the following is a prime mover in head...Ch. 11 - Where is the inferior oblique muscle located? in...Ch. 11 - What is the action of the masseter? swallowing...Ch. 11 - The names of the extrinsic tongue muscles commonly...Ch. 11 - What is the function of the erector spinae?...Ch. 11 - Which of the following abdominal muscles is not a...Ch. 11 - Which muscle pair plays a role in respiration?...Ch. 11 - What is the linea alba? a small muscle that helps...Ch. 11 - The rhomboid major and minor muscles are deep to...Ch. 11 - Which muscle extends the forearm? biceps brachii...Ch. 11 - What is the origin of the wrist flexors? the...Ch. 11 - Which muscles stabilize the pectoral girdle? axial...Ch. 11 - The large muscle group that attaches the leg to...Ch. 11 - Which muscle produces movement that allows you to...Ch. 11 - What is the largest muscle in the lower leg?...Ch. 11 - The vastus intermedius muscle is deep to which of...Ch. 11 - What effect does fascicle arrangement have on a...Ch. 11 - Movements of the body occur at joints. Describe...Ch. 11 - Explain how a synergist assists an agonist by...Ch. 11 - Describe the different criteria that contribute to...Ch. 11 - Explain the difference between axial and...Ch. 11 - Describe the muscles of the anterior neck.Ch. 11 - Why are the muscles of the face different from...Ch. 11 - Describe the fascicle arrangement in the muscles...Ch. 11 - What are some similarities and differences between...Ch. 11 - The tendons of which muscles form the rotator...Ch. 11 - List the general muscle groups of the shoulders...Ch. 11 - Which muscles form the hamstrings? How do they...Ch. 11 - Which muscles form the quadriceps? How do they...
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