PRINCIPLES OF LIFE
PRINCIPLES OF LIFE
3rd Edition
ISBN: 9781319017712
Author: HILLIS
Publisher: MAC HIGHER
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Chapter 10.1, Problem 1I

(a)

Summary Introduction

To determine: The genotype and phenotype of the diploid Neurospora cells if the mutation occurred on the same gene in these two strains.

Introduction: Haploid cells are the cells containing a single set of chromosomes. The fusion of haploid cells forms diploid cells having twice the number of chromosomes. Mutation in the gene causes the knockout of the gene, which means the gene becomes non-functional, and it fails to form an enzyme.

(b)

Summary Introduction

To determine: The genotype and phenotype of the diploid Neurospora cells, if the mutation occurred on the different genes in these two strains. The strains were unable to synthesize arginine.

Introduction: Mutation in a particular gene ceases the expression of a particular enzyme for which it codes. This mutation does not impact other genes. The rest of the genes are expressing and coding for a specific enzyme. Two cells with a mutation on different genes will have two different enzymes non-functional.

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*Example 2: Tracing the path of an autosomal dominant trait Trait: Neurofibromatosis Forms of the trait: The dominant form is neurofibromatosis, caused by the production of an abnormal form of the protein neurofibromin. Affected individuals show spots of abnormal skin pigmentation and non-cancerous tumors that can interfere with the nervous system and cause blindness. Some tumors can convert to a cancerous form. i The recessive form is a normal protein - in other words, no neurofibromatosis.moovi A typical pedigree for a family that carries neurofibromatosis is shown below. Note that carriers are not indicated with half-colored shapes in this chart. Use the letter "N" to indicate the dominant neurofibromatosis allele, and the letter "n" for the normal allele. Nn nn nn 2 nn Nn A 3 N-
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