Chapter 10, Problem 2TBP

calculate the questions showing the solution including variables,unit and equations all the questiosn below using the data.show solving and answer a) B1,   b) B2,   c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist t1/2,absorb f) t1/2,elim   k) apparent central compartment volume (V1,app) p) total AUC (using short cut method) apparent volume of distribution based on AUC (VAUC,app)  apparent clearance (CLapp)   absolute bioavailabilty of oral route ( AUCiv =116ml)

Please help me to draw this by hand. In as much detail as possible, hand draw a schematic diagram of the hypothalamic-pituitary-gonad (HPG) axis in the human female. Be sure to include all the relevant structures and hormones. You must define all abbreviations the first time you use them. Please include (and explain) the feedback loops.

Please refer below

AaBbCc X AaBbCc individuals are crossed. What is the probability of their offspring having a genotype AABBCC?

circle a nucleotide in the image

"One of the symmetry breaking events in mouse gastrulation requires the amplification of Nodal on the side of the embryo opposite to the Anterior Visceral Endoderm (AVE). Describe one way by which Nodal gets amplified in this region." My understanding of this is that there are a few ways nodal is amplified though I'm not sure if this is specifically occurs on the opposite side of the AVE.  1. pronodal cleaved by protease -> active nodal 2. Nodal -> BMP4 -> Wnt-> nodal 3. Nodal-> Nodal, Fox1 binding site  4. BMP4 on outside-> nodal  Are all of these occuring opposite to AVE?

If four babies are born on a given day What is the chance all four will be girls? Use genetics laws

Explain each punnet square results (genotypes and probabilities)

Give the terminal regression line equation and R or R2 value:   Give the x axis (name and units, if any) of the terminal line:   Give the y axis (name and units, if any) of the terminal line: Give the first residual regression line equation and R or R2 value: Give the x axis (name and units, if any) of the first residual line : Give the y axis (name and units, if any) of the first residual line: Give the second residual regression line equation and R or R2 value: Give the x axis (name and units, if any) of the second residual line: Give the y axis (name and units, if any) of the second residual line:  a) B1 Solution   b) B2   c)hybrid rate constant (λ1)   d)hybrid rate constant (λ2)   e) ka   f) t1/2,absorb   g) t1/2, dist   h) t1/2, elim   i)apparent central compartment volume (V1,app)   j) total AUC (short cut method)   k) apparent volume of distribution based on AUC (VAUC,app)   l)apparent clearance (CLapp)   m) absolute bioavailability of oral route (need AUCiv…