Concepts of Biology
1st Edition
ISBN: 9781938168116
Author: Samantha Fowler, Rebecca Roush, James Wise
Publisher: OpenStax College
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Chapter 10, Problem 13CTQ
Identify a possible advantage and a possible disadvantage of a genetic test that would identify genes in individuals that increase their probability of having Alzheimer’s disease later in life.
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Chapter 10 Solutions
Concepts of Biology
Ch. 10 - Figure 10.7 Why was Dolly a Finn-Dorset and not a...Ch. 10 - n gel electrophoresis of DNA, the different bands...Ch. 10 - In the reproductive cloning of an animal, the...Ch. 10 - What carries a gene from one organism into a...Ch. 10 - What is a genetically modified organism (GMO)? a....Ch. 10 - What is the role of Agrobacterium tumefaciens in...Ch. 10 - What is the most challenging issue facing genome...Ch. 10 - Genomics can be used in agriculture to: a....Ch. 10 - What kind of diseases are studied using...Ch. 10 - What is the purpose and benefit of the polymerase...
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- Glioblastoma multiforme (GBM) is the most commonand aggressive form of brain cancer in humans.Without any treatment, the mean survival rate is aboutthree months. Even with standard treatments such assurgical resection, radiation, and chemotherapy, themean survival rate is between seven and 14 months.GBM tumors differ in their spectrum of geneticchanges, and these changes may influence the effectof particular treatments. Answer the following questions about the relevance of particular mutations toparticular treatments and outcomes.a. Biopsies of about 20% of GBMs show the expression of a certain mutational variant of the EGFR(epidermal growth factor receptor) protein calledEGFRvIII. The same cancerous cells of theseGBMs also show the expression of normal, wildtype EGFR. Is the gene encoding EGFR a tumorsuppressor gene or a proto-oncogene?b. It is very difficult to induce cells expressingEGFRvIII to undergo apoptosis. If you werea radiologist treating a patient with a GBMthat expresses…arrow_forward. Discuss how Genome-wide association studies (GWAS) can be used to identify genetic risk loci for (a) diseases with complex inheritance and (b) pharmacogenomic genotype-phenotype associations. Draw on specific examples and experimental evidence in your discussion.arrow_forwardSuppose that you could undergo genetic testing at age 18 for susceptibility to a genetic disease that would not appear until middle age and has no available treatment. a. What would be some of the possible reasons for having such a genetic test and some of the possible reasons for not having the test? b. Would you personally want to be tested? Explain your reasoning.arrow_forward
- Which sequence variations are identified by NGS and in which format they are store Discuss in details the software used to identify the effect or nature of these variants. How this information can be used for personalized medicine.arrow_forwardMy professor instructed me to make a PowerPoint presentation on this topic " Prenatal Molecular Testing ". I have total 4 members in my group. Can you please divide the topic into 4 sub topic or parts? So that we can individually take preparation. I will rate you positive if you do so. Thank you so much. ?arrow_forward(2) Design an experiment on how would molecular genetic tools, such as DNA microarrays, be used to study human diseases, such as skin tumor cell growth or migration? How could they be used to study melanin expression in nomal skin cells? Rubric for Class Portfolio #1: Student creates an experiment with experimental and negative control group on hoW DNA microarrays can used to address how it can be used to monitor skin tumor cell growth and/or migration, as well as melanin gene expression.arrow_forward
- Inborn errors of immunity (IEls) are a heterogeneous group of disorders due to genetic defects in the immune response that have a broad clinical spectrum. Diagnosis of the precise genetic cause of IEI has led to improved care and treatment of patients; however, genetic diagnosis using standard approaches is only successful in -40% of patients and is particularly challenging in "sporadic" cases without a family history. Standard genetic testing for IEl evaluates for germline changes in genes encoding proteins important for the immune response. It is now clear that IEl can also arise from de novo mutations leading to genetic variants present in germ cells and/or somatic cells. What genetic mechanism has emerged as a significant and often potentially overlooked molecular mechanism of IEI? Single nucleotide variant (SNV) - A genetic change in a single nucleotide, for example the change of a guanine (G) to an alanine (A). This may or may not be associated with altered function of the…arrow_forwardRegarding albinism, with adavances in fields such as gene therapy and stem cell research, is there a therapeutic solution to this genetic disorder?arrow_forwardMention the advantages and the challenges of using SNP markers in DNA typing.arrow_forward
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