Human Anatomy
9th Edition
ISBN: 9780135168059
Author: Marieb, Elaine Nicpon, Brady, Patricia, Mallatt, Jon
Publisher: Pearson Education, Inc.,
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Textbook Question
Chapter 1, Problem 21RQ
(a) The human body is designed as a tube within a tube. List three organs that are part of the inner tube and three structures that are components of the outer tube. (b) Give an example of segmentation in the human body.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 1 Solutions
Human Anatomy
Ch. 1 - What is the difference between histology and...Ch. 1 - Use the word root definitions located in the end...Ch. 1 - Define a tissue. List the four types of tissues in...Ch. 1 - Name the organ system described in each of the...Ch. 1 - Using directional terms, desc1ibe the location of...Ch. 1 - Prob. 6CYUCh. 1 - What is the outer layer of serous membrane that...Ch. 1 - In tissue stained with H&E stain, what color are...Ch. 1 - Prob. 9CYUCh. 1 - What imaging technique is best suited for each of...
Ch. 1 - The correct sequence of levels forming the...Ch. 1 - Using the terms listed below, fill in the blank...Ch. 1 - Match each anatomical term for body regions listed...Ch. 1 - Which of these organs would not be cut by a...Ch. 1 - State whether each structure listed below is part...Ch. 1 - Indicate whether each of the following conditions...Ch. 1 - Prob. 7RQCh. 1 - The ventral surface of the body is the same as its...Ch. 1 - Match each serous membrane in column B with its...Ch. 1 - Prob. 10RQCh. 1 - Histology is the same as ta) pathological anatomy,...Ch. 1 - Describe the anatomical position and then assume...Ch. 1 - Identify the organ system that each group of...Ch. 1 - (a) Define bilateral symmetry. (b) Although many...Ch. 1 - The following advanced imaging techniques are...Ch. 1 - Give the formal regional term for each of these...Ch. 1 - Prob. 17RQCh. 1 - Construct sentences that use the following...Ch. 1 - The main cavities of the body include the...Ch. 1 - Where would you be injured it you pulled a muscle...Ch. 1 - (a) The human body is designed as a tube within a...Ch. 1 - Dominic's doctors strongly suspect he has a tumor...Ch. 1 - The Nguyen family was traveling in their van and...Ch. 1 - A patient had a hernia in his inguinal region,...Ch. 1 - A woman fell off a motorcycle. She tore a nerve in...Ch. 1 - New anatomy students oiten mix up the terms spinal...Ch. 1 - Using the list of word roots located at the...
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