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You have received a laboratory report showing the presence of a HIGH concentration of ketone bodies in the urine of a patient (ketosis). a) What disease would you suspect in this patient and why? b) Explain why ketone bodies accumulate in such patients, and the sequence of events that lead to their formation. Include the location, any pathways impacted, and the purpose of ketone formation. c) Give the names of the three different ketone bodies, and indicate which ones are used for fuel in extrahepatic cells. d) When ketones are used by extrahepatic cells for fuel, why is a new enzyme used in the pathway (why not simply reverse the pathway used to form ketones)? Explain.

You have received a laboratory report showing the presence of a HIGH concentration of ketone bodies in the urine of a patient (ketosis). a) What disease would you suspect in this patient and why? b) Explain why ketone bodies accumulate in such patients, and the sequence of events that lead to their formation. Include the location, any pathways impacted, and the purpose of ketone formation. c) Give the names of the three different ketone bodies, and indicate which ones are used for fuel in extrahepatic cells. d) When ketones are used by extrahepatic cells for fuel, why is a new enzyme used in the pathway (why not simply reverse the pathway used to form ketones)? Explain.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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You have received a laboratory report showing the presence of a HIGH concentration of ketone bodies in the urine of a patient (ketosis). a) What disease would you suspect in this patient and why? b) Explain why ketone bodies accumulate in such patients, and the sequence of events that lead to their formation. Include the location, any pathways impacted, and the purpose of ketone formation. c) Give the names of the three different ketone bodies, and indicate which ones are used for fuel in extrahepatic cells. d) When ketones are used by extrahepatic cells for fuel, why is a new enzyme used in the pathway (why not simply reverse the pathway used to form ketones)? Explain.
Transcribed Image Text:You have received a laboratory report showing the presence of a HIGH concentration of ketone bodies in the urine of a patient (ketosis). a) What disease would you suspect in this patient and why? b) Explain why ketone bodies accumulate in such patients, and the sequence of events that lead to their formation. Include the location, any pathways impacted, and the purpose of ketone formation. c) Give the names of the three different ketone bodies, and indicate which ones are used for fuel in extrahepatic cells. d) When ketones are used by extrahepatic cells for fuel, why is a new enzyme used in the pathway (why not simply reverse the pathway used to form ketones)? Explain.
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