Answered: Why would the failure of the p53 tumor…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Related questions

Question

Why would the failure of the p53 tumor supressor gene be more likely to cause cancer in a seventy year old person compared to a ten year old person?

Group of answer choices

A. the p53 gene never works well in old people

B. cells divide more rapidly as people get older

C.The seventy year old is more likely to have pre-existing failures in cell cycle control

D. there are fewer mutations in genes controlling the cell cycle in older people

Expert Solution

Step 1

Tumor protein p53, which plays a crucial role in the cellular response to DNA damage, is one of the most essential tumor suppressors. In reaction to damaged DNA and other adverse circumstances, p53 inhibits cell cycle progression at the G1 checkpoint (regulating the G1 to S transition). When a cell's DNA is broken, a sensor protein activates p53, which triggers the synthesis of a cell-cycle inhibitor, halting the cell cycle at the G1 checkpoint.