Why is it necessary to resolve chiral pharmaceuticals (why cant we just use racemic versions)? What are the important criteria of a good resolving reagent? In particular why is (S)- methylbenzylamine a suitable resolving agent for ibuprofen

Q: ind an example of a chiral molecule in biology whose enantiomers have markedly different functions.…

A: Enantiomers are the molecules that are mirror images of each other but they are non-superimposable.…

Q: Calculate the enantiomeric excess for the sample of (S)- ibuprofen sample and (R)-ibuprofen sample…

A: Given, Amount of (S) - ibuprofen recovered from polarimetry = 0.745 g Amount of (R) - ibuprofen…

Q: How does NH3 acts as a complexing agent?

A: Lewis Base : A molecule with a donatable lone pair of elctron is called a Lewis base. e.g. NH3

Q: Suggest a reason why decane1CH3CH2CH2CH2CH2CH2CH2CH2CH2CH32 does not exhibitliquid crystalline…

A: Since to exhibit liquid crystalline behaviour the molecules should not tend to coil in any random…

Q: (9) Which of the following molecules might also make a suitable resolving agent for ibuprofen?…

A: Ibuprofen reacts with chiral amines and forms diastereomers. These diastereomers are seperable using…

Q: 3) Your results should show that S-mandelic acid rotates light to the right and R-mandelic acid…

A: “Since you have asked multiple questions, we will solve the first question for you. If you want any…

Q: Calculate the index of hydrogen deficiency of this compound  Q.)Dopamine, C8H11NO2

A: Index of hydrogen deficiency gives the number of hydrogen molecules required to be added to get a…

Q: Explain the process of Calculating Enantiomeric Excess ?

A: The absolute difference between the mole fraction of two enantiomers is termed as enantiomers.

Q: What reagents can be used to this picture? Choices : Potassium permanganate, Pyridinium…

A:

Q: The method of assay for sulfonamides is? Kjeldahl method   Diazotization method   Gravimetric…

A: The solution is given below -

Q: Illustrate A splitting diagram for the Hb protons in CH3CH2CH2Z ?

A:

Q: 1. It measures how good chiral molecules are able to rotate plane, polarized light. A. Specific…

A: Since you have asked multiple question, we will solve the first question for you. If you want any…

Q: Which method can be used to prepare CH3CH2CH2CH2NH2? NH3 (large excess) (a) CH3CH2CH2CH2Br -> (1)…

A: Butyl amine or the given product can be formed by various types of reaction using different…

Q: N(CH3)3 12. is a chiral quaternary ammonium salt. Provide the two Newman projections (from different…

A: We have to provide Newman projections for givwn chiral quaternary ammonium salt. From the C3—C2 and…

Q: 12. Using a suitable example, explain (using structures) what is meant by a meso compound. Draw the…

A:

Q: Using the infrared spectra provided assign peaks to the functional groups in (a)…

A: A question based on IR spectroscopy of organic molecules. 6 molecules are given whose IR peaks are…

Q: Perspective drawings of both entantiomers of CHBrIF. Make models of both enantiomers (make one model…

A: Both entantiomers of CHBrIF can be drawn as follows,

Q: H d a H3C- e EN H

A:

Q: How many atoms share the unpaired electron in semiquinone?

A: The structure of semiquinone is shown below. The semiquinone is a radical, it means that it has one…

Q: Explain why compounds of Zn2+ are white, but compounds ofCu2+ are often blue or green?

A: Zn2+ has the electronic configuration of [Ar] 3d10 with all the electrons paired in the d-orbitals.…

Q: Perform a stereochemical analysis of the final hydrobenzoin product, indicating which pairs are…

A: Enantiomers are the stereoisomers which are non-superimposible mirror images of each other…

Q: Why ester C=O has higher stretching frequency than amide?

A: The functional present in any molecule is detected by IR spectroscopy. Interaction between the IR…

Q: 23. The IR spectrum below has the nitrile functional group. Discuss the similarities between the…

A: IR spectroscopy used for the distinguish between different compounds. IR spectroscopy identify…

Q: „CN and ČN

A: Conformational sterioisomers   wrt X and 2 hydrogens, the groups are the  Axial(Upwards) position…

Q: Describe two methods for resolving (separating) a pair of enantiomers.

A: Enantiomer: Isomer which are nonsuperimposable mirror images of each other called enantiomer.…

Q: .Use the flow chart/methodology (Figure 15.7, pg656) to determine if the protons in the ollowing…

A: If a ligand are interchanged by the axis of symmetry, then such ligands are said to be homotopic. If…

Q: What is the impact of molecular chirality on the pharmacological activity of drugs, and how can it…

A: Introduction:The impact of molecular chirality on the pharmacological activity of drugs is a…

Q: Explain the difference between an enantiomer and an epimer. a. Enantiomers are…

A: Optical activity: molecule or substances that can rotate the plane-polarized light are said to be…

Q: Which of the statements below is FALSE regarding SN2 reactions?

A:

Q: Even though you used different amounts of NaSCN for each test mixture the values of Kc you measured…

A: Equilibrium constant (Kc) for this reaction :…

Q: below? d6-DMSO solution -a.55 -G.45 -0.35 La30 La2s -0.20 Lais 0.00 3.05

A: The characteristic peak is at 4.7ppm which is due to strong dis

Q: When a new chirality center is created, isomers can result. For the reaction below, draw all of the…

A: -> NaCN has -CN nucleophile which can give addition reaction to carbony center which is…

Q: Molnupiraviris a promising drug candidate that is discovered to treat patients with Covid-19. The…

A: A question based on stereochemistry, which is to be accomplished.

Q: Can you give an example of homotopic, heterotopic, enantiotopic, and diastereotopic for compounds?

A: Topicity is the stereochemical relationship between substituents and the structure to which they are…

Q: Draw a tetrahedral representation of the (2S,4S) enantiomer of 2-bromo-4-chlorohexane. • Use the…

A: Given,Compound : Objective : Draw tetrahedral representation of (2S,4S) enantiomer of

Q: Select one: True or False

A: According to question  1) True  Pure covalent bonded molecules, don't have high polarity, that's why…

Q: Could an ir spectrum effectively determine the identity and ratio of isomeric products? Or can NMR…

A: Given :  Could an ir spectrum effectively determine the identity and ratio of isomeric products?…

Q: My lab report result：Why does the melting point (70-71) match neither the enantiomers’ nor the…

A: In the above example , it clearly indicates that, it is quite easy to determine the purity if any…

Q: E). Provide the absolute configuration of each chiral center (R, S or none). i) Lowest CIP priority…

A: In chemistry, the Cahn-Ingold-Prelog (CIP) priority rules are used to assign priorities to different…

Q: Two enantiomers can be separated by the process of resolution. Describe How ?

A: Two enantiomers can be separated by the process of resolution has to be described below.

Q: What is the requirement for a molecule to be active in the Infra Red region?

A: Requirement for molecule to be active in the Infra Red region:

Q: why are these sterically hindered what does it even mean to be stericaly hindered

A: Primary alkylhalides undergo substitution reaction through SN2 reaction. In this reaction, substrate…

Q: How can IR spectroscopy be used to distinguish between each pair of isomers?

A: The first two isomers can be distinguished on the basis of carbonyl stretching frequency. The IR…

Q: (b) What information do the cross peaks of COSY and NOESY offer? Explain.

A: Answer -

Q: The two enantiomers of a chiral compound are present in the ratio 50:25. What is the enantiomeric…

A: So enantiomeric excess  = % of major enantiomer - % of minor enantiomer