Why does a folded mutant protein aggregate rather than remain a misfolded monomer?
Proteins
We generally tend to think of proteins only from a dietary lens, as a component of what we eat. However, they are among the most important and abundant organic macromolecules in the human body, with diverse structures and functions. Every cell contains thousands and thousands of proteins, each with specific functions. Some help in the formation of cellular membrane or walls, some help the cell to move, others act as messages or signals and flow seamlessly from one cell to another, carrying information.
Protein Expression
The method by which living organisms synthesize proteins and further modify and regulate them is called protein expression. Protein expression plays a significant role in several types of research and is highly utilized in molecular biology, biochemistry, and protein research laboratories.
Why does a folded mutant protein aggregate rather than remain a misfolded monomer?
Proteins are essential molecules in biological systems, and their proper folding is crucial for their functions. However, sometimes proteins can misfold due to mutations or other factors, leading to various diseases. When a mutant protein misfolds, it can either aggregate or remain a misfolded monomer.
Misfolding due to Mutation
- A mutation in the gene encoding a protein can alter its amino acid sequence.
- Mutations can disrupt the native, stable structure that the protein would typically adopt.
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