Why did AZT fail to control HIV-1 infections in the long term? AZT treatment selected for HIV-1 virions with reverse transcriptase variants that did not incorporate AZT, but this was not heritable so humans progressed to AIDS anyway HIV-1 evolved AZT resistance in one person and that resistant strain spread to other people AZT treatment had harsh side effects so patients could not stick to a treatment regimen AZT treatment selected for HIV-1 virions with reverse transcriptase variants that did not incorporate AZT, and since this was heritable the population of virions evolved resistance within the host

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Why did AZT fail to control HIV-1 infections in the long term?
AZT treatment selected for HIV-1 virions with reverse transcriptase variants that did not
incorporate AZT, but this was not heritable so humans progressed to AIDS anyway
HIV-1 evolved AZT resistance in one person and that resistant strain spread to other people
AZT treatment had harsh side effects so patients could not stick to a treatment regimen
AZT treatment selected for HIV-1 virions with reverse transcriptase variants that did not
incorporate AZT, and since this was heritable the population of virions evolved resistance
within the host
Transcribed Image Text:Why did AZT fail to control HIV-1 infections in the long term? AZT treatment selected for HIV-1 virions with reverse transcriptase variants that did not incorporate AZT, but this was not heritable so humans progressed to AIDS anyway HIV-1 evolved AZT resistance in one person and that resistant strain spread to other people AZT treatment had harsh side effects so patients could not stick to a treatment regimen AZT treatment selected for HIV-1 virions with reverse transcriptase variants that did not incorporate AZT, and since this was heritable the population of virions evolved resistance within the host
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