While we are at it, let's do the same thing for the second step of the mechanism. Again, what is happening with the arrows circled in red below? Cys157 Cys157 Cys157 His296 His296 His296 OH HO HO HN, HN, HN Co2 Asn329 Asn329- Asn329- Cys157 His296 он „OH HNNH Asn329 O deprotonation of the conjugate acid form of imidazole, followed by general base assistance in decarboxylation nucleophilic addition of the cysteine side chain to imidazole O decarboxylation coupled with the generation of molecular hydrogen (H2) O general acid catalyzed isomerization covalent attachment of the substrate to the enzyme

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
Question
While we are at it, let's do the same thing for the second step of the mechanism. Again, what is
happening with the arrows circled in red below?
Cys157
Cys157
Cys157
His296
His296
His296
OH
OH
HN,
HN
HN
-CO2
CH2
Asn329
Asn329
Asn329-
Cys157
His296
OH
OH
HNNH HyC.
H,C.
Asn329-
O deprotonation of the conjugate acid form of imidazole, followed by general base assistance in decarboxylation
O nucleophilic addition of the cysteine side chain to imidazole
O decarboxylation coupled with the generation of molecular hydrogen (H2)
O general acid catalyzed isomerization
n covalent attachment of the substrate to the enzyme
Transcribed Image Text:While we are at it, let's do the same thing for the second step of the mechanism. Again, what is happening with the arrows circled in red below? Cys157 Cys157 Cys157 His296 His296 His296 OH OH HN, HN HN -CO2 CH2 Asn329 Asn329 Asn329- Cys157 His296 OH OH HNNH HyC. H,C. Asn329- O deprotonation of the conjugate acid form of imidazole, followed by general base assistance in decarboxylation O nucleophilic addition of the cysteine side chain to imidazole O decarboxylation coupled with the generation of molecular hydrogen (H2) O general acid catalyzed isomerization n covalent attachment of the substrate to the enzyme
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Designing a Synthesis
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY