Which product would be obtained if 3-methyl-2-butanol was used as the alcohol in the Electrophilic Aromatic Substitution: Friedel-Crafts Alkylation? Show the structure of the product. Explain briefly. Original reaction and more info is attached:
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
Which product would be obtained if 3-methyl-2-butanol was used as the alcohol in the Electrophilic
Original reaction and more info is attached:
![In this experiment, the tert.-butyl cation is produced by the reaction of tert. butanol and
concentrated sulfuric acid. A tert.-butyl cation will be used and since no carbocation rearrangement
can occur, any method can be used to produce this cation. Just remember that while anhydrous
AlCl3 is often used for Friedel-Craft reactions, this class of EAS simply requires a carbocation,
regardless of how it is generated.
In the current experiment, a different electrophile (the tert.-butyl cation) is used to alkylate
1,4-dimethoxybenzene. This is a Friedel-Crafts Alkylation reaction.
LOCH3
(H;C);C.
LOCH3
(CH3);COH
CH;COOH/H,SO4
H3CO
H3CO
`C(CH3)3
The primary difference between Friedel-Crafts EAS reactions and other EAS reactions
(i.e., nitration, halogenation, etc.) is that in a Friedel-Crafts reaction (alkylation or acylation), the
electrophile is a carbon atom (i.e., in this experiment it is a tert.-butyl carbocation). In many cases,
the Friedel-Crafts electrophile is generated using a chlorine-containing molecule (i.e., an acyl
[acid] chloride or an alkyl chloride) and an appropriate Lewis acid (i.e., AIC13, BF3) catalyst](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff6d90194-f69b-4828-8987-5b7d7a46128d%2F24124031-50b7-44bc-89e8-871d384d0860%2Ffsdj7kr_processed.png&w=3840&q=75)
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