Which of the following is true about integral membrane proteins 1. They are always alpha helical 2. They only contain beta sheets 3. They are usually unfolded 4. They usually have long stretches of hydrophobic residues
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Which of the following is true about integral membrane proteins
1. They are always alpha helical
2. They only contain beta sheets
3. They are usually unfolded
4. They usually have long stretches of hydrophobic residues
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- Which plasma membrane component can be either found on its surface or embedded in the membrane structure? a. protein b. cholesterol c. carbohydrate d. phospholipidWhich one of the these primary protein structures is most likely to form an alpha helix that would would cross a plasma membrane from the extracellular side to the cytoplasmic side? The N terminus is outside the cell and the C terminus is inside the cell in this example. Use the diagram provided to decode the one letter amino acid abbreviations. Nonpolar side chains No charged or electro- negative atoms to form hydrogen bonds; not soluble in water Polar side chains Partial charges can form hydrogen bonds; soluble in water Electrically charged side chains Charged side chains form hydrogen bonds; highly soluble in water H H₂N-C-C H₂N-C- H₂N+ Glycine (G) Gly H H H₂N* Methionine (M) Met C 8*CH₂ 6 OH 2011 Pearson Education, Inc. CH₂ CH₂ S CH₂ =0 Serine (S) Ser c=0 O O Aspartate (D) Asp 20 H₂N-C- с CH₂ H₂N* HO Acidic Alanine (A) Ala H L CH C H₂N-C C CH₂ CH₂ Threonine (T Thr H₂N C Phenylalanine (F) Phe O 0=0 CH₂ CH₂ Glutamate (E) Glu ON-DTNLRRSIAGLLIRHKKE - COOH H₂N+…Which of the following correctly describes the structure of the phospholipid bilayer in plasma membranes? The polar hydrophilic groups of each leaflet face outward, toward the aqueous environment on either side of the membrane. A The non-polar hydrophobic groups of each leaflet face inward, toward each other. The non-polar hydrophilic groups of each leaflet face outward, toward the aqueous environment on either side of the membrane. B The polar hydrophobic groups of each leaflet face inward, toward each other. The polar hydrophilic groups of each leaflet face inward, toward each each other. The non-polar hydrophobic groups of each leaflet face outward, toward the aqueous environment on either side of the membrane. The non-polar hydrophilic groups of each leaflet face inward, toward each each other. The polar hydrophobic groups of each leaflet face outward, toward the aqueous environment on either side of the membrane.
- Which of the following statements is false? Integral membrane proteins cannot, in general, be extracted from a cell without disruption of the membranes. The portion of an integral membrane protein that traverses the membrane has, in general, hydrophobic amino acid residues on the surface and hydrophilic amino acid residues in the interior. Peripheral membrane proteins can often be extracted from a membrane surface using a buffer with a high [salt]. Proteins can be tethered to a membrane via a lipid prosthetic group. Unless attached to the cytoskeleton, membrane lipids diffuse about the membrane surface.Glycolipids in the plasma membrane are located at: 1.Inner leaflet of the plasma membrane 2.The outer leaflet of the plasma membrane 3.Evenly distributed in the inner and outer leaflets 4.It varies according to cell typesWhich of the following statements is/are incorrect? 1. The cell membrane is purely hydrophobic. 2. Glycerophospholipids have a phosphate derivative group that is known as the polar head group. 3. The individual glycerophospholipid molecules that aggregate become covalently linked to each other to form a lipid bilayer. 4. The interfacial region of a lipid bilayer is polar due to the polar head groups of the lipid molecules that make up the bilayer. O 1 and 3 O 1 only O 2 and 4 O 3 only O 4 only
- Drawn below is a schematic of a transmembrane protein. Extracellular Cell membrane Cytosolic side (a) From the list below, select the amino acid(s) that might by more common in the extracellular domain of this membrane protein and whose side- chain can form hydrogen bonds with the surrounding water molecules. Explain why you selected this option(s). Lysine Serine Phenylalanine Methionine (b) From the list below, select the amino acid(s) that would likely be found in the transmembrane/ membrane spanning domain of this protein and whose side- chain interacts with the lipid bilayer. Lysine Serine Phenylalanine MethionineWhich of the following lipid components of the eukaryotic plasma membrane would be associated with the highest membrane fluidity? a triglyceride with unbranched, saturated, short-chain fatty acids a monoglyceride with unbranched, saturated, short-chain fatty acids a triglyceride with unbranched, saturated, long-chain fatty acids a monoglyceride with branched, unsaturated, short-chain fatty acids a diglyceride with unbranched, saturated, long-chain fatty acidsThe plasma membrane is composed of a variety of lipid molecules. 1. Phosphatidylethanolamine 2. Phosphatidylcholine 3. Phosphatidylinositol 4. Phosphatidylserine 5. Sphingomyelin 6. Glycolipids 7. Cholesterol. Which lipids contain sugar molecules?
- Two theories of membrane structure are discussed below. Unit Membrane Model Phospholipid molecules are the most abundant type of lipids in cell membranes. Each consists of a nonpolar, hydrophobic tail, and a polar, hydrophilic head. The phospholipid chains orient themselves to form a bilayer with the tails pointed inward and the hydrophilic heads lined up on both sides of the bilayer. An extended monomolecular layer of protein coats both the outside of the membrane and the inside of the bilayer, but the protein does not penetrate the bilayer. When thin slices of membranes were examined with an electron microscope, three layers were seen: two electron-dense layers, with one wider layer between them. It was believed that the electron-dense layers represented proteins, and the lighter area represented lipids. Fluid Mosaic Model The structure of the fluid mosaic membrane is a bilayer of phospholipid molecules with proteins inserted into the bilayer. Hydrophilic regions of both the lipids…According to the fluid mosaic model of cell membranes, which of the following is a true statement about membrane phospholipids? They frequently flip-flop from one side of the membrane to the other. They have hydrophilic tails in the interior of the membrane. They can move laterally along the plane of the membrane. They are free to depart from the membrane and dissolve in the surrounding solution.There is a long chain of amino acids with long sections that are mostly polar, alternating with long sections that are nonpolar. How would this chain be organized if it were destined to become a transmembrane protein? A cytoplasmic protein?