Which of the following doesn't occur in the inflammatory response? O A. Decreased vascular permeability O B. Extravasation of leukocytes into inflammed tissue O C. Endothelial cell activation D. Tissue injury repair E. Local blood clotting

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### Understanding the Inflammatory Response

**Question:**
Which of the following doesn't occur in the inflammatory response?

**Options:**
- A. Decreased vascular permeability
- B. Extravasation of leukocytes into inflamed tissue
- C. Endothelial cell activation
- D. Tissue injury repair
- E. Local blood clotting

In the context of the inflammatory response, several physiological processes occur to address injury or infection. Let's examine each of the provided options:

1. **Decreased Vascular Permeability:**
   - Typically, during inflammation, vascular permeability actually **increases** to allow immune cells and proteins to move from the bloodstream to the site of injury. Therefore, decreased vascular permeability is not a characteristic of the inflammatory response.

2. **Extravasation of Leukocytes into Inflamed Tissue:**
   - **Extravasation** is the process by which white blood cells (leukocytes) move out of the circulatory system and towards the site of tissue damage or infection. This is a critical component of the inflammatory response.

3. **Endothelial Cell Activation:**
   - Endothelial cells line the blood vessels and play an essential role in inflammation by becoming activated. This activation leads to the expression of adhesion molecules that facilitate the recruitment of leukocytes to the inflamed tissue.

4. **Tissue Injury Repair:**
   - The inflammatory response includes mechanisms that not only contain and remove the pathogen but also initiate tissue repair processes. This is an integral part of resolving inflammation.

5. **Local Blood Clotting:**
   - Blood clotting, or coagulation, at the site of injury is a response to prevent excessive bleeding and to provide a temporary matrix for tissue repair. This process is often associated with inflammation.

**Conclusion:**
Based on the typical characteristics of the inflammatory response, the correct answer is:

**A. Decreased vascular permeability**

This option does not occur as part of the inflammatory response, given that inflammation is associated with an increase in vascular permeability.
Transcribed Image Text:### Understanding the Inflammatory Response **Question:** Which of the following doesn't occur in the inflammatory response? **Options:** - A. Decreased vascular permeability - B. Extravasation of leukocytes into inflamed tissue - C. Endothelial cell activation - D. Tissue injury repair - E. Local blood clotting In the context of the inflammatory response, several physiological processes occur to address injury or infection. Let's examine each of the provided options: 1. **Decreased Vascular Permeability:** - Typically, during inflammation, vascular permeability actually **increases** to allow immune cells and proteins to move from the bloodstream to the site of injury. Therefore, decreased vascular permeability is not a characteristic of the inflammatory response. 2. **Extravasation of Leukocytes into Inflamed Tissue:** - **Extravasation** is the process by which white blood cells (leukocytes) move out of the circulatory system and towards the site of tissue damage or infection. This is a critical component of the inflammatory response. 3. **Endothelial Cell Activation:** - Endothelial cells line the blood vessels and play an essential role in inflammation by becoming activated. This activation leads to the expression of adhesion molecules that facilitate the recruitment of leukocytes to the inflamed tissue. 4. **Tissue Injury Repair:** - The inflammatory response includes mechanisms that not only contain and remove the pathogen but also initiate tissue repair processes. This is an integral part of resolving inflammation. 5. **Local Blood Clotting:** - Blood clotting, or coagulation, at the site of injury is a response to prevent excessive bleeding and to provide a temporary matrix for tissue repair. This process is often associated with inflammation. **Conclusion:** Based on the typical characteristics of the inflammatory response, the correct answer is: **A. Decreased vascular permeability** This option does not occur as part of the inflammatory response, given that inflammation is associated with an increase in vascular permeability.
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