Which cytochrome P450-catalyzed reaction is shown below?R-CH2NH2[R-CH=NH]Oxidation of aromatic aminesOxidative deaminationOxidative O-dealkylationOxidative N-dealkylationpara-hydroxylationR-CHO + NH3

Cytochrome P450 is an enzyme that catalyzes various reactions such as oxidation, hydroxylation,…

Answered: Which cytochrome P450-catalyzed…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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All of the following are true about the cytochrome P450 system except: 13 A) This system contains Phase II biotransforming enzymes B) The highest concentration of P450 enzymes is in the liver endoplasmic reticulum All P450 enzymes are heme containing proteins P450 enzymes play a key role in the detoxification of xenobiotics
Interestingly, the most common treatment for methanol poisoning is to use ethanol as an antidote. Why would adding large amounts of ethanol help slow down the rate of formic acid production by aldehyde dehydrogenase?
When alanine undergoes transamination with oxaloacetate, alanine is first converted to alpha-keto acid. The enzyme uses PLP as a cofactor. Suggest a mechanism for this conversion starting with Schiff base PLP-ENZ. Remember to name the resulting alpha-keto acid.
What if C-1 of the oxaloacetate were labeled instead, when would the label be released as CO2?
Cytochrome P450 (CYP450) monoxygenase is the enzyme involved in Phase I metabolism. 450 refers to: * It can metabolize 450 drugs when in the reduced form and complexed to carbon monoxide It can produce 450 drugs when in the oxidized form and complexed to carbon dioxide It can emit light at 450 nm when in the oxidized form and complexed to carbon monoxide It can absorb light at 450 nm when in the reduced form and complexed to carbon dioxide It can absorb light at 450 nm when in the reduced form and complexed to carbon monoxide
Draw the major product of the following Sonogashira coupling reaction. [Pd], pyrrolidine, TBAB + =Ph H₂O, reflux Draw the major product(s) of the following alkene (olefin) metathesis reaction. Ar + N ROW RO
Based on the image below, select the correct statements. Note: There may be more than 1 correct response. Ribose 5-phosphate ribose phosphate pyrophosphokinase (PRPP synthetase) glutamine-PRPP amidotransferase adenylosuccinate synthetase AMP -> PRPP 5-Phosphoribosylamine I adenylosuccinate lyase 9 steps Adenylosuccinate AMP IMP <-- ADP <- AMP <-- GMP <-- IMP IMP dehydrogenase <- GMP. XMP ADP ATP XMP-glutamine amidotransferase GMP يا Increased levels of ADP inhibit the production of PRPP. Increased levels of GMP inhibit the production of XMP. Increased ADP activates PRPP synthase to increase PRPP levels. Increased IMP activates glutamine-PRPP amidotransferase to further increase IMP levels.
Which of the following statements is true for the shown reaction? Substrate level phosphorylation occurs during the reaction Phosphoryl transfer occurs during the reaction Both A and B Neither A nor B
The citric acid cycle enzyme at which FADH2 is generated is: A) isocitrate dehydrogenase. B) x-ketoglutarate dehydrogenase. C) succinate dehydrogenase. OD) malate dehydrogenase.
Which of the following statements regarding the active site of cytochrome P450s is correct? Cytochrome P450-catalyzed monooxygenation proceeds with low stereoselectivity Cytochrome P450-catalyzed monooxygenation requires two electrons supplied by the redox process involving NADPH and NADP+. The 5th distal position (below the plane of the porphyrin ring) in cytochrome P450 is always occupied by His Cytochrome P450 is responsible for the metabolism of the minority of prescription drugs Cytochrome P450 contains manganese
The cytochrome P450 family of monooxygenase enzymes are involved in the clearance of drugs/medications from our body. Many adverse drug -drug interactions are known to occur as a result of interaction with the cytochrome P450 enzymes. A large number of drugs are metabolized by the enzyme P450 3A4. Human P450 3A4 is known to metabolize midazolam, a sedative, to a hydroxylated product, 1'- hydroxymidazolam. The kinetic data shown below are for the reaction catalyzed by P450 3A4. a. Focusing on the first 2 columns, determine the Km and Vmax for the P450 3A4 enzyme. b. Ketoconazole, an antifungal drug, is known to cause adverse drug interactions when taken along with midazolam. Using the data in the table, determine the type of inhibition caused by ketoconazole. Explain how you arrived at your answer. Midazolam (uM) 00 AN1 2 14 8 Rate of product formation (pmol min-1) 100 156 222 323 Rate of product formation in presence of ketoconazole pmol min-1) 11 18 27 40
In a P450 cycle, as shown in figure, ferrodoxin and ferrodoxin reductase are needed to form Fe (III) to Fe (III)-OOH. But why the peroxide shunt are also able to complete this process independent of Fd system (ferrodoxin and ferrodoxin reductase...)?

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Which cytochrome P450-catalyzed reaction is shown below? R-CH,NH2 [R-CH=NH] Oxidation of aromatic amines Oxidative deamination Oxidative O-dealkylation Oxidative N-dealkylation para-hydroxylation R-CHO + NH3